Tests a scan to guide adrenal surgery in primary aldosteronism
Tests a gallium-68 pentixafor PET scan in adults with primary aldosteronism.
Plain-language title generated from the registry record
Registry title: PETAL Trial: Impact of Gallium-68 Pentixafor PET-CT on Surgical Outcomes in Primary Aldosteronism
Key facts
- Where
- Seoul, South KoreaSee the 2 sites
Where in South Korea
- Samsung Medical CenterSeoul, South KoreaTaking people
- Seoul National University HospitalSeoul, South KoreaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Seoul National University Hospital
- Trial code
- NCT07027254
- Record updated
- 18 June 2025
- Original description
This study is a randomized controlled trial to assess the clinical utility of gallium-68 pentixafor PET/CT in the management of primary aldosteronism (PA). We aim to evaluate whether the addition of 68Ga-pentixafor PET/CT to standard adrenal venous sampling (AVS) improves surgical outcomes in patients with unilateral PA.Read full original descriptionShow less
A Randomized Controlled Trial to Evaluate the Effect of Gallium-68 Pentixafor PET-CT on Surgical Outcomes in Patients With Primary Aldosteronism (The PETAL Trial)
This study is a randomized controlled trial to assess the clinical utility of gallium-68 pentixafor PET/CT in the management of primary aldosteronism (PA). We aim to evaluate whether the addition of 68Ga-pentixafor PET/CT to standard adrenal venous sampling (AVS) improves surgical outcomes in patients with unilateral PA.
Inclusion: Age ≥19 years; Diagnosed with PA per 2016 Endocrine Society guidelines; Underwent adrenal CT; Signed informed consent.
Exclusion: Individuals who refuse to undergo surgery; Individuals who refuse or experience adverse effects from dexamethasone premedication required for 11C-Metomidate PET/CT; Individuals for whom 68Ga-Pentixafor PET/CT, 11C-Metomidate PET/CT, or adrenal venous sampling (AVS) is not feasible or is refused due to underlying conditions; Individuals with a history of abdominal open surgery or retroperitoneal surgery on the same side as the planned adrenalectomy; Women who are pregnant, breastfeeding, or may become pregnant; Any individual deemed unsuitable for the study at the discretion of the investigator.