Under construction – not a live service
Sign in
Taking people in ItalyPhase 3

Tests a urea toe nail patch in adults with fragile, fungal or psoriatic nails

Tests a urea nail patch against a placebo patch in adults with toenail problems.

Key facts

Who runs it
Wooshin Labottach Co., Ltd.
Where
Milan, ItalySee the site
Trial code
Registry title
Study to Assess Efficacy, Safety and Tolerability of a Nail Patch in Patients With Nail Fragility, Mychosis, Psoriasis
Status
Recruiting
Phase
Phase 3
People taking part
72 people, planned
Started
Feb 2026
Expected to end
Dec 2026
Type of study
Interventional, 2 groupsOne group gets a placebo (a dummy treatment), for comparison.
Treatments tested
  • Cosmetic patch containing urea applicated daily for 3 months
  • Placebo patch application
Record updated
26 January 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with fragile toenails, a fungal infection at the tip of the nail, or nail psoriasis. They test a nail patch against a placebo patch.

Age
18 years or older
Sex
All sexes can join
Disease stage
Fragile nails, fungal infection at the distal (tip) end of the nail, or nail psoriasis. The nail bed involvement must be 75% or less.
Earlier treatment
No antifungal or anti-psoriasis nail cream within the past 1 month. No antifungal tablets or injections within the past 3 months. No other nail study in the past 3 months.

Main reasons for not taking part

  • Fungal infection that reaches the base of the nail or covers more than 75% of the nail
  • Other conditions that change the look of the nails, weak immune system, or severe poor blood flow in the limbs
  • Known allergy to any of the study treatments
  • Active or severe psoriasis elsewhere on the body, or other autoimmune or inflammatory diseases
  • Other unrelated nail disorders, including genetically caused nail deformity

The registry criteria, word for word

Show all 8 criteriaShow less

Who can take part

  • aged 18 years or older Fragility Nails Distal Subungual Onychomycosis Nail Psoriasis affecting ≤75% of the nail bed according to a photographic documentation and to a subjective evaluation by the Investigator

Who cannot take part

  • Patients who have participated in another clinical nail study during the previous three months
  • Patients with conditions known to cause abnormal nail appearance, immunosuppression and signs of severe peripheral circulatory insufficiency
  • Patients who have a known allergy to any of the study treatments
  • Patients with unrelated nail disorders: onychomycosis, nail psoriasis, genetically induced onychodystrophy
  • Patients with other nail disorders, active or severe psoriasis elsewhere, other autoimmune or inflammatory diseases
  • Patients that have proximal subungual onychomycosis, if their distal subungual onychomycosis is extended into the proximal portion of the nail or if it affects >75% of the nail
  • Patients who had used topical antifungal, anti-psoriasis nail treatment within one month or systemic antifungal treatment within three months

Where in Italy

  • Clinica Dermatologica - Policlinico - Università degli Studi di Milano Via Francesco Sforza- MilanoMilan, ItalyContact: Paolo Bortoluzzi, PhdTaking people

About the trial

What the trial wants to find out

A randomized, double blind, placebo-controlled, unicenter, parallel group study to assess the efficacy, safety and tolerability of a multi-funtion toe nail patch in patients affected by nail fragility, nail mychosis and psoriasis 72 patients in 6 subgroups Treatment duration 3 months + 1 month follow-up

The 2 groups in the trial

  • EXPERIMENTAL COSMETICTreatment being tested

    APPLICATION OF THE EXPERIMENTAL PATCH WITH COSMETIC

    Treatment: Cosmetic patch containing urea applicated daily for 3 months

  • PlaceboPlacebo, for comparison

    Application of the Placebo patch

    Treatment: Placebo patch application

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
A Randomized, Double Blind, Placebo-controlled, Unicenter, Parallel Group Study to Assess the Efficacy, Safety and Tolerability of a Multi-funtion Toe Nail Patch in Patients Affected by Nail Fragility, Nail Mychosis and Psoriasis
Plain-language title
Tests a urea toe nail patch in adults with fragile, fungal or psoriatic nailsGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
26 January 2026