Brain Imaging Study Comparing Brain Activity in Women With Osteoporosis
Compares brain activity scans in postmenopausal women with and without osteoporosis and fractures.
Plain-language title generated from the registry record
Registry title: Resting-state Imaging and OSteoporosiS
Key facts
- Where
- Clermont-Ferrand, FranceSee the site
Where in France
- CHU de Clermont-FerrandClermont-Ferrand, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Clermont-Ferrand
- Trial code
- NCT07030205
- Record updated
- 13 May 2026
- Original description
This study will be conducted in 20 postmenopausal healthy volunteers, 20 postmenopausal osteoporotic patients with fracture and 20 postmenopausal osteoporotic women without fracture, in order to compare functional connectivity between brain areas. Participants will complete different questionnaires and tests assessing cognition, quality of life, sleep, physical activity, pain, anxiety and depression. A biological sample will be performed in order to evaluate different markers of bone remodeling. A Resting-state functional magnetic resonance imaging (rs-fMRI) will be realized in order to establish functional connectivity between brain regions.Read full original descriptionShow less
Resting-state Imaging and OSteoporosiS
This study will be conducted in 20 postmenopausal healthy volunteers, 20 postmenopausal osteoporotic patients with fracture and 20 postmenopausal osteoporotic women without fracture, in order to compare functional connectivity between brain areas. Participants will complete different questionnaires and tests assessing cognition, quality of life, sleep, physical activity, pain, anxiety and depression. A biological sample will be performed in order to evaluate different markers of bone remodeling. A Resting-state functional magnetic resonance imaging (rs-fMRI) will be realized in order to establish functional connectivity between brain regions.
Inclusion: Women aged 50 or over, with postmenopausal osteoporosis, fractured or not, diagnosed by their rheumatologist,; Able to give informed consent to participate in the research,; Affiliation with the French Social Security; Women aged 50 or over,; Bone densitometry performed as part of the protocol, not suggestive of osteoporosis and validated by investigators,; Matched to patients by age, menopausal status, socio-educational level and manual laterality,; Able to give informed consent to participate in the research,; Affiliation with the French Social Security; Registration or acceptance of registration in the national register of volunteers participating in Research.
Exclusion: Presence of medical devices (implants or prostheses),; Presence of pacemaker,; Incompatibility of the patient with the safety criteria of the medical imaging center for carrying out magnetic resonance experiments at 3 Tesla,; Contraindications to the realization of MRI without injection such as claustrophobia proven, hearing aid, pacemaker wearers, wearing a brain clip,; Refusal to be informed in the event of the accidental discovery of an anomaly during the resting state functional magnetic resonance imaging,; Woman under legal protection or deprived of liberty,; Refusal to participation.