Compares plant and meat protein diets in older adults with obesity and muscle loss
Tests legume, meat, or mixed protein diets with strength training in older adults with obesity.
Plain-language title generated from the registry record
Registry title: Plant vs Animal-based Protein Sources as an Anabolic and Metabolic-protective Options for SO in Older Adults
Key facts
- Where
- Tel Aviv, IsraelSee the site
Where in Israel
- Tel-Aviv Sourasky Medical CenterTel Aviv, IsraelNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Tel-Aviv Sourasky Medical Center
- Trial code
- NCT07030738
- Record updated
- 22 June 2025
- Original description
This study is testing how different types of protein - from red meat, legumes (like lentils and beans), or a mix of both - affect muscle strength, body composition, and metabolic health in older adults with obesity who are also at risk for sarcopenia (loss of muscle mass and function). Participants will follow a personalized weight loss diet with one high-protein meal each day that includes either red meat, legumes, or both, along with a home-based strength training program. The study will last three months and will include health assessments such as blood tests, muscle and fat measurements, and physical function tests. The goal is to find out which type of protein source is most helpful for improving strength, reducing body fat, and supporting healthy aging.Read full original descriptionShow less
Plant (Legumes) vs Animal-based (Meat) Protein Sources as an Anabolic and Metabolic-protective Options for Sarcopenic Obesity in Older Adults- A Randomized Controlled Trial
This study is testing how different types of protein - from red meat, legumes (like lentils and beans), or a mix of both - affect muscle strength, body composition, and metabolic health in older adults with obesity who are also at risk for sarcopenia (loss of muscle mass and function). Participants will follow a personalized weight loss diet with one high-protein meal each day that includes either red meat, legumes, or both, along with a home-based strength training program. The study will last three months and will include health assessments such as blood tests, muscle and fat measurements, and physical function tests. The goal is to find out which type of protein source is most helpful for improving strength, reducing body fat, and supporting healthy aging.
Inclusion: Aged 55 years or older; Diagnosed with obesity; At risk for sarcopenia, based on at least one of the following: Low score on the validated SARC-F-calf questionnaire (as suggested in prior studies). More than one comorbidity associated with sarcopenic obesity (e.g., diabetes, osteoporosis, cardiovascular disease, etc.). Polypharmacy: taking 8 or more prescribed medications. Evidence of strength or functional impairment, assessed using validated measurements at the baseline visit.
Exclusion: Recent use of steroid agents within the past 6 months (replacement therapy is allowed); Currently undergoing nutritional therapy, have recently changed diet (<1 month), or are enrolled in active weight-loss programs or therapies (including lifestyle and/or pharmacotherapy). Note: Patients stable on GLP-1 agonists or other pharmacotherapy are eligible; Diagnosis of malignancy within the past 5 years, except for non-melanoma skin cancer; Chronic kidney disease (CKD) at stage >1 (due to protein restriction needs); Recent (≤6 months) or unstable cardiovascular condition, or NYHA Class III or higher congestive heart failure; Vegetarians/vegans, or individuals with aversion or allergy to all legumes or all red meat products; Other medical, psychiatric conditions, or lab abnormalities that may pose a risk to participation; Uncorrected hypothyroidism: TSH > 6 mIU/L; Currently performing resistance training; Habitual consumption of more than 3 servings/week of either legumes or red meat.