Frontlight ResearchEarly access
CompletedNo phase
Therapeutic Effect of Oral Hyaluronic Acid on Knee Osteoarthritis
Key facts
- Who runs it
- Taichung Veterans General Hospital
- Where
- Taiwan1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 44 people enrolled
- Started
- 21 Apr 2023
- Ended
- 17 Feb 2025
- Type of study
- Interventional, 2 groupsOne group gets a placebo (a dummy treatment), for comparison.
- Treatments tested
- oral hyaluronate and injection
- hyaluronate injection
- Record updated
- 4 November 2026
Who can take part
- Age
- 60 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- Radiological evidence of osteoarthritis Kellgren-Lawrence grade 1-3
- Had knee effusion at the suprapatellar recess under ultrasonographic examination
- Age greater than 60 years old
- Refractory to conservative treatments (oral analgesics, physical therapy, or previous intra-articular injections)
Who cannot take part
- Rheumatological disorders
- Central nervous system disorders including stroke, Parkinsonism, and spinal cord disorders
- Accidental trauma or fractures involving knees in the past three months
- Neuropathic pain involving lower limbs
- Depression and cognitive problems
- Pregnancy
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The goal of this clinical trial is to investigate the effect of oral hyaluronate in patients with knee osteoarthritis. The main question it aims to answer is: the therapeutic effect in the combined treatment of oral nutritional supplement based on hyaluronic acid with hyaluronic acid intra-articular Injection on symptomatic knee osteoarthritis. Researchers will compare it to those who receive only hyaluronic acid injection to see if the combined treatment is better.
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Participants will receive a total of three months of oral hyaluronate or placebo agents.
The 2 groups in the trial
- oral hyaluronate plus hyaluronate knee injectionTreatment being tested
Treatment: oral hyaluronate and injection
- hyaluronate knee injectionPlacebo, for comparison
Treatment: hyaluronate injection
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Therapeutic Effect of Combined Treatment of Oral Nutritional Supplement Based on Hyaluronic Acid With Hyaluronic Acid Intra-articular Injection on Symptomatic Knee Osteoarthritis
- Record updated
- 4 November 2026