Studying clot and blood cells in patients with stroke from blocked brain arteries
Studies clots removed from the brain and blood samples in adults with acute ischemic stroke.
Plain-language title generated from the registry record
Registry title: Study of Inflammatory Cells in the Blood and Cerebral Thrombus of Patients Affected by Cerebral Ischemia
Key facts
- Where
- Milan, ItalySee the site
Where in Italy
- NeurologyMilan, ItalyNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- IRCCS San Raffaele
- Trial code
- NCT07033988
- Record updated
- 24 June 2025
- Original description
This is an observational, prospective and retrospective, single-center study of thrombotic material and blood samples obtained from patients undergoing mechanical endovascular thrombectomy for ischemic stroke caused by large vessel occlusion or stenosis.Read full original descriptionShow less
Insights Into Cerebral Clot Biomarkers and Inflammatory Pathways
This is an observational, prospective and retrospective, single-center study of thrombotic material and blood samples obtained from patients undergoing mechanical endovascular thrombectomy for ischemic stroke caused by large vessel occlusion or stenosis.
The overarching aim of this study is to advance the understanding of the pathogenesis of cerebral ischemia and to support the development of novel therapeutic strategies for cerebrovascular disease. Specifically, the research seeks to elucidate the pathophysiological mechanisms involved in thrombus formation and stabilization that lead to ischemic events, identify thrombus compositions associated with distinct stroke etiologies, and determine features predictive of resistance to current intravenous thrombolytic therapies. In addition, the study aims to discover novel therapeutic targets and to identify circulating blood biomarkers indicative of an elevated risk of thrombosis.
Inclusion: Age ≥ 18 years; Presentation to the emergency department with symptoms and/or signs suggestive of:; An acute cerebrovascular event; Stroke mimics; Stroke-related risk factors (e.g., atrial fibrillation, endocarditis, significant internal carotid stenosis, neoplasms, systemic infections); Undergoing one of the following treatments:; Mechanical thrombectomy; Intravenous thrombolysis; Standard medical therapy; Provision of informed consent, either:; Directly from the conscious patient; Via appropriate procedures for unconscious patients.
Exclusion: Presence of a known autoimmune disease that could interfere with the interpretation of biomarker analyses; Pregnancy or breastfeeding.