Two Drugs Compared to Calm Airway Stress During Brain Surgery Recovery
Compares two drugs to calm airway stress in adults with high blood pressure.
Plain-language title generated from the registry record
Registry title: Dexmedetomidine vs Labetalol for Airway Stress in Hypertensive Craniotomy Patients
Key facts
- Where
- Cairo, EgyptSee the site
- Phase
- Phase 4
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 30 and 60 years old?
Source: NCT07034898, who can take part
Where in Egypt
- Ain Shams UniversityCairo, EgyptNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Ain Shams University
- Trial code
- NCT07034898
- Record updated
- 24 June 2025
- Original description
This randomized trial compares dexmedetomidine and labetalol in controlling airway and hemodynamic stress during extubation in hypertensive patients undergoing craniotomy. Outcomes include extubation quality, vital signs, sedation, and adverse effects.Read full original descriptionShow less
A Randomized Comparative Study of Dexmedetomidine Versus Labetalol in Attenuating Airway Stress Response in Hypertensive Patients Undergoing Craniotomy
This randomized trial compares dexmedetomidine and labetalol in controlling airway and hemodynamic stress during extubation in hypertensive patients undergoing craniotomy. Outcomes include extubation quality, vital signs, sedation, and adverse effects.
Inclusion: Age between 30 and 60 years; American Society of Anesthesiologists (ASA) physical status II; Diagnosed hypertension; Scheduled for elective craniotomy under general anesthesia; Able and willing to provide informed consent.
Exclusion: ASA physical status III or IV; Uncontrolled comorbidities (e.g., diabetes mellitus); Coagulopathy or current use of anticoagulant or antiplatelet therapy; Known allergy or hypersensitivity to dexmedetomidine or labetalol; Emergency craniotomy; Pregnant or breastfeeding women; Patients with a history of severe cardiac arrhythmias; Inability to provide informed consent.