Exercise Program for Physical Recovery After Chronic Stroke
Tests a modified cardiac rehabilitation exercise program in adults with chronic stroke.
Plain-language title generated from the registry record
Registry title: Physical Capacity Building for Chronic Stroke
Key facts
- Where
- Charleston, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07039305, who can take part
Where in United States
- Medical University of South CarolinaCharleston, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Medical University of South Carolina
- Trial code
- NCT07039305
- Record updated
- 8 December 2025
- Original description
Cardiac rehabilitation is the standard-of-care treatment option for patients with cardiovascular disease and has been shown to improve many aspects critical to patient recovery. Investigators believe that individuals who have had a stroke need to be treated similarly. Investigators will study the effects of a comprehensive modified cardiac rehabilitation program to determine if it can improve some of the physical and psychosocial problems common in survivors of stroke with and without depression.Read full original descriptionShow less
Modified Cardiac Rehabilitation to Enhance Post-Stroke Physical and Psychosocial Function: Does Depression Limit the Response?
Cardiac rehabilitation is the standard-of-care treatment option for patients with cardiovascular disease and has been shown to improve many aspects critical to patient recovery. Investigators believe that individuals who have had a stroke need to be treated similarly. Investigators will study the effects of a comprehensive modified cardiac rehabilitation program to determine if it can improve some of the physical and psychosocial problems common in survivors of stroke with and without depression.
Inclusion: Age 18-80; A diagnosis of stroke at least 6 months prior; Residual paresis in the lower extremity (Fugl-Meyer lower extremity [LE] motor score <34); Ability to walk without assistance and without an AFO during testing and training at speeds ranging from 0.2-1.0 m/s; Ability to follow instructions, complete cognitive testing and to communicate exertion, pain and distress; No antidepressant medications or no change in doses of psychotropic medication for at least 4 weeks prior to the study (6 weeks if newly initiated medication); HDRS17 question #3 and PHQ-9 question #9 regarding suicide ≤ 2; Provision of informed consent; In addition, depressed subjects will screen for probable major depressive disorder (Patient Health Questionnaire-9 ≥ 10) and be diagnosed using the Structured Clinical Interview for Depression (SCID) according to the DSM-5.
Exclusion: Electronic or metallic implants; Unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during ADL's; Dementia; History of DVT or pulmonary embolism within 6 months; Uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions; Severe hypertension with systolic >200 mmHg and diastolic >110 mmHg at rest; Severe cognitive impairment (MoCA score ≤15); History of seizures; Unable to ambulate at least 150 feet or experienced intermittent claudication while walking; Life expectancy <1 yr; Attempt of suicide in the last 2 years or suicidal risk assessed by depression screening; Current enrollment in a rehabilitation trial to enhance motor, cognitive and or psychosocial recovery; Moderate to severe neglect that precludes cognitive testing; For brain stimulation procedures only:; Women of child bearing potential.