Impact of Severe Obstructive Sleep Apnea-Hypopnea Syndrome on Auditory-Cognitive Processing
Key facts
- Where
- Beijing, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 20 and 60 years old?
Source: NCT07039500, who can take part
Where in China
- Peking University First HospitalBeijing, ChinaContact: Caifeng Xia, M.D.Taking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Peking University First Hospital
- Trial code
- NCT07039500
- Record updated
- 7 August 2025
- Original description
The goal of this observational study is to learn how severe obstructive sleep apnea-hypopnea syndrome (OSAHS) affects the brain's ability to process sounds and attention in adults aged 20-60 years. The main questions it aims to answer are:Read full original descriptionShow less
The goal of this observational study is to learn how severe obstructive sleep apnea-hypopnea syndrome (OSAHS) affects the brain's ability to process sounds and attention in adults aged 20-60 years. The main questions it aims to answer are:
1. Does severe OSAHS change how the brain automatically detects sound changes during wakefulness? 2. Does severe OSAHS reduce people's ability to pay attention to important sounds when awake? 3. Can brainwave tests (Electroencephalogram, EEG) detect early signs of hearing-related cognitive problems in OSAHS patients before symptoms appear?
Researchers will compare two groups:
* 50 adults with severe OSAHS (diagnosed by sleep tests) * 50 healthy adults matched by age and gender
Participants will:
* Complete hearing tests (MoCA) * Undergo a 1-night sleep test (PSG) * Wear an EEG cap for 1.5-2 hours while listening to sounds in a quiet room:
* Passive task: Relax (no response needed) * Active task: Press a button when hearing rare sounds * Receive ¥75/hour compensation for their time
Inclusion: All Participants:; Aged 20-60 years; Normal hearing (PTA ≤25 dB HL at 0.5,1,2,4 kHz; Type A tympanogram); MoCA score ≥26; Willing to complete EEG testing; OSAHS Group Additional:; PSG-confirmed severe OSAHS (AHI >30 events/hour); Control Group Additional:; Self-reported absence of snoring/sleep disorders; No prior OSAHS diagnosis.
Exclusion: Chronic steroid use; History of:; Schizophrenia, epilepsy, Parkinson's, TBI, or language disorders; Middle/inner ear diseases (otitis media, acoustic neuroma, etc.); Cognitive impairment or depression/anxiety disorders; Systemic inflammatory diseases or malignancies; All Participants:; Pregnancy or suspected pregnancy (self-reported).