Lifestyle program for brain health in older adults at risk of Alzheimer disease
Tests yoga, diet, and brain training in older adults at higher Alzheimer risk.
Plain-language title generated from the registry record
Registry title: Lifestyle for the BRAin Health - Time Restricted Eating and Mindfulness
Key facts
- Where
- Brno, CzechiaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 60 and 80 years old?
Source: NCT07042087, who can take part
Where in Czechia
- Fnusa/ IcrcBrno, CzechiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- St. Anne's University Hospital Brno, Czech Republic
- Trial code
- NCT07042087
- Record updated
- 27 June 2025
- Original description
The study aims to evaluate the effects of a 9-month intervention combining yoga-based mindfulness techniques, cognitive training, and nutritional counseling on cognitive function, plasma markers of neurodegeneration (tau protein), physical fitness, and metabolism in older adults at increased risk of developing Alzheimer's disease.Read full original descriptionShow less
Lifestyle for the BRAin Health - Time Restricted Eating and Mindfulness
The study aims to evaluate the effects of a 9-month intervention combining yoga-based mindfulness techniques, cognitive training, and nutritional counseling on cognitive function, plasma markers of neurodegeneration (tau protein), physical fitness, and metabolism in older adults at increased risk of developing Alzheimer's disease.
Inclusion: Age 60-80 years; Diagnosis of Subjective Cognitive Impairment (SCI) or Mild Cognitive Impairment (MCI); mini-mental-scale (MMSE) score between 24-30; Positive plasma pTau217 biomarker; Stable dose of iAChE therapy (if applicable); Ability to participate in a 9-month intervention.
Exclusion: Concurrent participation in another clinical study; Unstable iAChE medication regimen; Stroke or myocardial infarction within the past year; Decompensated internal conditions (e.g., severe heart failure, kidney failure, unstable diabetes, GLP1 agonist therapy); Long-term psychiatric treatment (except well-managed depression); Neurological conditions affecting mobility or cognition (e.g., Parkinson's disease, severe tremor, epilepsy); Severe sensory or motor impairment preventing protocol participation; Active cancer treated within the past 5 years; Poor anticipated compliance (e.g., transport issues, time constraints, non-cooperation); Substance or alcohol dependence.