Taking people in BrazilNo phase

Tests a sleep breathing device in people recovering from ischemic stroke

Tests CPAP, a breathing device for sleep apnea, in adults with ischemic stroke.

Key facts

Who runs it: Hospital das Clínicas de Ribeirão Preto
Where: Ribeirão Preto, BrazilSee the site
Trial code: NCT07044830
Registry title: Obstructive Sleep Apnea Treatment From Acute to Chronic Phase of Stroke
Status: Recruiting
People taking part: 425 people, planned
Started: 28 Feb 2024
Expected to end: 28 Feb 2031
Type of study: Interventional, 5 groupsOne group gets an existing treatment, for comparison.
Treatments tested: CPAP
Record updated: 1 July 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults aged 18 to 80 who had a new ischemic stroke. It tests early CPAP treatment for sleep apnea to see if it helps recovery.

Age: 18 to 80 years
Sex: All sexes can join.
Disease stage: A new ischemic stroke in the upper brain (supratentorial, not lacunar). Symptoms started or were noticed less than 12 hours before admission. Stroke severity score (NIHSS) of 4 to 20.
Earlier treatment: People who already use CPAP, or whose earlier CPAP failed, cannot join.

Main reasons for not taking part

A previous stroke
A known sleep apnea diagnosis with current CPAP use or earlier failed CPAP
Disability before the stroke (mRS above 1)
Coma, stupor, or a breathing tube in the windpipe
Pregnant or suspected pregnant women

The registry criteria, word for word

Show all 19 criteriaShow less

Who can take part

Supratentorial non-lacunar ischemic stroke, including anterior, middle, and posterior cerebral artery territories
Aged 18 to 80 years
Symptom onset or symptom recognition to admission < 12 hours
NIHSS score ≥ 4 and ≤ 20 at enrollment
Signed informed consent form obtained from the participant or their legal representative

Who cannot take part

Prior stroke
Previous diagnosis of OSA with current CPAP use or previously failed CPAP
Oxygen therapy >2 L/min
Chronic alcohol or drug use with high risk of withdrawal during hospitalization
Pre-stroke disability (mRS > 1)
Clinical instability or severe pre-existing illness (e.g., heart failure, oxygen-dependent COPD, renal or hepatic failure)
Known severe neurological disease (e.g., dementia, Parkinson's disease, multiple sclerosis, or other neurodegenerative conditions)
Coma or stupor
Orotracheal intubation
Psychomotor agitation
High likelihood of neurosurgical intervention within the first 48 hours
Pregnant or suspected pregnant women
Inability to complete follow-up for any reason
Any contraindication to CPAP use

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 18 and 80 years old?

Where in Brazil

Hospital das Clínicas, Ribeirão Preto Medical School, University of São PauloRibeirão Preto, BrazilContact: Millene Camilo, MD, PhDTaking people

About the trial

What the trial wants to find out

The study aims to evaluate whether early treatment of obstructive sleep apnea with continuous positive airway pressure in ischemic stroke patients has a favorable effect on functional recovery.

The 5 groups in the trial

Severe OSA treatedExisting treatment, for comparison
AHI≥30: treated with CPAP
Treatment: CPAP
Severe OSA untreatedNo study treatment, for comparison
AHI≥30: without CPAP
No OSANo study treatment, for comparison
AHI\<5
Mild OSANo study treatment, for comparison
5≥AHI\<15
Moderate OSANo study treatment, for comparison
15≤AHI\<30