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Magnetic stimulation with arm training for arm weakness after stroke

Tests magnetic brain stimulation with arm training in adults recovering from stroke.

Key facts

Who runs it
Ruijin Hospital
Where
Shanghai, ChinaSee the site
Trial code
Registry title
Individualized rTMS Synchronized Task Training for Closed-loop Neuromodulation of Post-stroke Motor Dysfunction
Status
Not yet recruiting
People taking part
51 people, planned
Started
20 Jul 2025
Expected to end
20 May 2028
Type of study
Interventional, 3 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • Individualized online stimulation
  • Non-individualized online stimulation
  • Sham stimulation
Record updated
3 July 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults aged 20 to 80 with upper limb movement problems after a first stroke. It tests magnetic brain stimulation (rTMS) together with movement training.

Age
20 to 80 years
Sex
All sexes can join.
Disease stage
First stroke, confirmed by a neurological exam, CT or MRI. Vital signs are stable and the upper limb has some movement problem. Subacute or chronic phase.
Biomarker or test result
Motor evoked potentials (MEPs) of the First Dorsal Interosseous Muscle (FDI) or Abductor Pollicis Brevis Muscle (APB) must be negative in the affected side of the brain. MMSE score of 20 points or more.

Main reasons for not taking part

  • Severe heart, lung, liver or kidney disease, or a malignant tumor
  • History of aphasia, severe cognitive impairment or mental illness
  • Epileptic seizure in the last month, or recent use of anti-epileptic drugs
  • Metal implants, a pacemaker, skull defects or other reasons that prevent TMS
  • Severe vision or hearing problems that prevent normal communication

The registry criteria, word for word

Show all 13 criteriaShow less

Who can take part

  • The patient is first diagnosed with stroke through neurological examination, CT or MRI scan
  • The vital signs are stable and there is a certain degree of upper limb motor dysfunction
  • Motor evoked potentials(MEPs) of First Dorsal Interosseous Muscle（FDI）or Abductor Pollicis Brevis Muscle (APB) is negative in ipsilesional hemisphere
  • The age is between 20 and 80 years old
  • The cognitive ability is not significantly affected and the patient can cooperate with various examinations and assessments, with a MMSE score ≥ 20 points
  • There are no serious complications (such as pneumonia, heart failure, urinary tract infection or malnutrition)
  • There is no pathological condition that is a contraindication for TMS in the medical history (for example, patients with metal in the brain, such as aneurysm clips, patients with a cardiac pacemaker, pregnant women, or those with a history of epileptic seizures)
  • The patient or guardian agrees to sign the informed consent form

Who cannot take part

  • Patients with severe heart, lung, liver, kidney diseases and malignant tumors
  • Those with a history of aphasia, severe cognitive impairment or mental illness
  • Patients who have had a history of epileptic seizures in the last month or are taking anti-epileptic drugs recently
  • People with metal implants, pacemakers, skull defects or other conditions that prevent them from undergoing TMS
  • Those with severe visual or hearing impairments, unable to communicate normally

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 20 and 80 years old?

Where in China

  • Shanghai Ruijin Hospital, affiliated to Shanghai Jiao Tong University, School of medicine,Shanghai, ChinaContact: Yifeng WANGNo longer taking part

About the trial

What the trial wants to find out

The goal of this clinical trials is to investigate the effectiveness of individualized online repetitive transcranial magnetic stimulation (rTMS) in enhancing upper limb motor rehabilitation during the subacute and chronic phase of stroke. It will also learn about the safety of online rTMS intervention methods. The main questions it aims to answer are:

Read full original descriptionShow less

1. Does individualized rTMS precise target combined with motor training improve upper limb motor rehabilitation in patients？ 2. Does individualized rTMS precise target combined with motor training enhance the upper limb motor rehabilitation ability in stroke patients by strengthening the functional coupling of the motor circuit to achieve functional reorganization of the brain network ?

Researchers will compare individualized online rTMS to non-individualized online and individualized sham stimulation in stroke patients to see if individualized online rTMS works to alleviate motor dysfunction in this randomized，sham-controlled, double-blind trial.

Participants will:

1. randomized to one group(individualized online, non-individualized online or sham); 2. receive rTMS treatment for 10 days, with 5 working days per week for a total of two weeks; 3. receive magnetic resonance imaging (MRI) and electroencephalogram (EEG) evaluations before and after the entire treatment; 4. conduct scales and MEP assessment one day before the treatment, as well as one day, one month, and three months after the treatment.

The 3 groups in the trial

  • Individualized online stimulationTreatment being tested

    The individualized online stimulation group will calculate precise targets based on the collected multimodal MRI (structural images, resting-state/task-state functional images, and diffusion tensor imaging), plan the coil position and placement angle of TMS through electric field simulation, and achieve individualized intervention. At the same time, when patients receive TMS treatment, they are paired with specific upper limb motor tasks. When the task starts autonomously, TMS stimulation is triggered by acceleration-EMG feedback. When the task stops or is completed, TMS stimulation also stops immediately according to the acceleration-EMG feedback to achieve real-time effects.

  • Non-individualized online stimulationExisting treatment, for comparison

    In the non-individualized online stimulation group, patients receive TMS treatment synchronized with task training. However, the targeting uses traditional positioning methods, i.e., determining the target with a positioning cap instead of precise target localization.

  • Sham stimulationSham treatment, for comparison

    In the individualized online sham stimulation group, patients receive TMS treatment combined with specific tasks. The stimulation targets are the same as those in the online stimulation group, all determined by precise target localization, except that a sham stimulation coil is used for TMS stimulation.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Individualized Closed-Loop Neuromodulation With Repetitive Transcranial Magnetic Stimulation Synchronized Task Training for Upper Limb Motor Dysfunction in Stroke Patients
Plain-language title
Magnetic stimulation with arm training for arm weakness after strokeGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Fit questions
Built from NCT07049211, who can take part
Record updated
3 July 2025