Hyperbaric Oxygen Therapy After Endovascular Treatment for Acute Ischemic Stroke
Tests hyperbaric oxygen therapy in adults with acute ischemic stroke after endovascular treatment.
Plain-language title generated from the registry record
Registry title: Hyperbaric Oxygen After Stroke Thrombectomy: A Multicenter Randomized Trial on Safety and Efficacy
Key facts
- Where
- Beijing, ChinaSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 35 and 75 years old?
Source: NCT07049692, who can take part
Where in China
- Beijing Chaoyang Hospital, Capital Medical UniversityBeijing, ChinaNot yet recruiting
- Emergency Intensive Care UnitBeijing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Beijing Chao Yang Hospital
- Trial code
- NCT07049692
- Record updated
- 24 July 2026
- Original description
1. The goal of this clinical trial is to evaluate the efficacy and safety of hyperbaric oxygen (HBO)in stroke patients after endovascular treatment 2. The main questions it aims to answer is:Read full original descriptionShow less
Evaluation of the Efficacy and Safety of Hyperbaric Oxygen in Patients After Endovascular Treatment for Acute Ischemic Stroke: A Multicenter, Open-label, Randomized Controlled Clinical Trial
1. The goal of this clinical trial is to evaluate the efficacy and safety of hyperbaric oxygen (HBO)in stroke patients after endovascular treatment 2. The main questions it aims to answer is:
Whether HBO can improve the prognosis of ischemic stroke patients after endovascular treatment? 3. Participants will:
receive HBO (1.6 Atmosphere Absolute，1.6ATA)，Once a day, for 1 hour each time, for 5 days a week (it can be non-consecutive days), the total course of treatment is 10 times.
undergo three scheduled face to face or telephone follow-up assessments during the 12-month period following HBO.
Inclusion: 35-75 years; The symptoms and signs are consistent with acute anterior circulation ischemic stroke. The immediate postoperative angiographic recanalization grade was ≥ 2b; Neurological deficit score at the time of enrollment: 5 ≤ NIHSS ≤ 15 points; Consciousness status (NIHSS 1a-1b items): 0-1 point; Pre-stroke functional status (mRS score): 0-1; Time from surgery to randomization grouping: ≤ 72 hours; Patient or legal representative who signed the informed consent form; Preoperative CT angiography or magnetic resonance angiography confirmed large vessel occlusion (internal carotid artery or middle cerebral artery M1 segment) that was consistent with the symptoms and signs; And the area supplied by the middle cerebral artery in the brain is less than 1/3; A lberta S troke P rogram E arly C T S core ≥ 6.
Exclusion: Currently involving in the research of other projects related to drugs or medical devices; Postprocedural imaging identified either procedure-related subarachnoid hemorrhage or hemorrhagic transformation; Severe heart, liver and kidneys failure; Unstable vital signs (heart rate ≤ 50 beats/min or ≥ 120 beats/min, oxygen saturation ≤ 90%, respiration ≥ 30 breaths/min or ≤ 10 breaths/min); Hypertension that cannot be controlled by medication: Systolic blood pressure ≥ 160 mmHg, or diastolic blood pressure ≥ 100 mmHg; Suspected of having acute myocardial infarction; CT angiography or magnetic resonance angiography confirmed the presence of cerebral vasculitis or cerebral vasculitis syndrome; Hereditary or acquired bleeding tendency, deficiency of coagulation factors, recent use of oral anticoagulants with an international normalized ratio (INR) > 3 or activated partial thromboplastin time (APTT) exceeding the normal value by more than 3 times; Baseline platelet count < 50×10 9/L; Baseline blood glucose is less than 2.78 mmol/L or greater than 22.2 mmol/L; Subjects with HBO contraindications or intolerance; Based on the medical history, it is suspected that the cerebral embolism is caused by sepsis or infective endocarditis; Expected lifespan < 90 days; Pregnancy; CT or MRI scans revealed intracranial tumors (except for cerebellar meningiomas) and intracranial arteriovenous malformations; Based on the medical history and CT or MRI findings, a diagnosis of internal carotid artery dissection or aortic dissection is suspected; Based on the medical history and CT or MRI findings, cerebral vasculitis is suspected; Based on the clinical evidence of multiple vascular regions being occluded (either in the bilateral anterior circulation or anterior/posterior circulation) or bilateral infarction or multi-region infarction as detected by CT angiography or magnetic resonance angiography; CT or magnetic resonance imaging shows a significant midline shift effect (> 0.5 cm).