Studying kidney disease and heart failure in people with obesity
Compares how kidneys handle protein and salt in people with heart failure and obesity.
Key facts
- Who runs it
- University of Mississippi Medical Center
- Where
- Jackson, United StatesSee the site
- Trial code
- Registry title
- The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity
- Status
- Recruiting
- People taking part
- 60 people, planned
- Started
- 22 Jul 2022
- Planned end
- 31 Jul 2026
- Type of study
- Observational, 3 groups
- Treatments tested
- High protein and sodium meal
- Record updated
- 4 July 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18-75 in three groups: healthy people, people with obesity but no heart failure, and people with obesity and heart failure with preserved ejection fraction (HFpEF). It studies how the kidneys handle protein and salt.
- Age
- 18 to 75 years
- Sex
- All sexes can join.
- Disease stage
- Healthy group: normal kidney function and no heart failure. Obesity group: eGFR 60 or higher and no heart failure. HFpEF group: eGFR 60 or higher and a diagnosis of HFpEF.
- Earlier treatment
- People must be able to stop NSAIDs. People with a history of kidney replacement therapy, kidney transplant, cancer, chemotherapy or radiation (HFpEF group) cannot join.
- Biomarker or test result
- Healthy group: BMI 25-30 kg/m2. Obesity groups: BMI above 35 kg/m2. HFpEF group: LVEF above 55% on echo, H2FPEF score 6-9 or HFA-PEFF score 5 or 6.
Main reasons for not taking part
- Pregnant or breastfeeding
- Allergic or skin reaction to iodine-based contrast dye
- Acute illness or hospital stay within the last 3 months
- Hemoglobin below 7
- Current nicotine or recreational drug use, or chronic heavy drinking
The registry criteria, word for word
Show all 43 criteriaShow less
Who can take part
- Adults 18-75 years old
- Normal kidney function
- No heart failure
- BMI 25-30kg/m2
- Adults 18-75 years old
- eGFR >= 60 mL/min/1.73m2
- BMI > 35 kg/m2
- Adults 18-75 years old
- eGFR >= 60 mL/min/1.73m2
- BMI > 35 kg/m2
- Diagnosis of HFpEF (chart diagnosis, LVEF > 55% on echo, H2FPEF score 6-9 or HFA-PEFF score 5 or 6
Who cannot take part
- Current use of nicotine or recreational drugs, chronic drinker; Criteria for Cohort 2: Obese Participants without HFpEF
- Current use of nicotine or recreational drugs, chronic drinker; Criteria for Cohort 3: HFpEF and Obese Participants
- Current use of nicotine or recreational drugs, chronic drinker
- Diagnosis of chronic illness
- History of cutaneous or allergic reaction to iodine-based products of contrast dyes
- Acute illness or hospitalization event within 3 months
- Comorbid conditions: MM, amyloidosis, pheochromocytoma, SCD, metastatic brain lesions, advanced kidney disease, liver dysfunction, endotoxemia, hyperthyroidism
- Diagnosis of Heart Failure
- Diagnosis of chronic illness
- History of cutaneous or allergic reaction to iodine-based products of contrast dyes
- Acute illness or hospitalization event within 3 months
- Comorbid conditions: MM, amyloidosis, pheochromocytoma, SCD, metastatic brain lesions, advanced kidney disease, liver dysfunction, endotoxemia, hyperthyroidism
- History of RRT or kidney transplant
- Acute illness/hospitalization in the past 3 months
- History of cancer, chemo, or XRT
- History of allergies to contrast
- Comorbid conditions: MM, amyloidosis, pheochromocytoma, SCD, metastatic brain lesions, advanced kidney disease, liver dysfunction, endotoxemia, hyperthyroidism
- eGFR<60mL/min/1.73m2
- Hemoglobin levels <7mg/dL
- eGFR<60mL/min/1.73m2
- Hemoglobin levels <7mg/dL
- Hemoglobin < 7
- Pregnancy or breast feeding
- Unable to stop NSAIDs
- Pregnancy or breast feeding
- Unable to stop NSAIDs
- NYHA class III/IV
- Urinary retention screen +
- Mobility issues
- Pregnant/breastfeeding
- Unable to stop NSAIDs
Other criteria
- Criteria for Cohort 1: Healthy Participants
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Where in United States
- University of Mississippi Medical CenterJackson, United StatesContact: Tekka JohnsonTaking people
About the trial
What the trial wants to find out
This research study wants to learn about Chronic Kidney Disease (CKD) with Obesity, and Heart Failure with preserved Ejection Fraction (HFpEF) and better ways to evaluate these diseases. HFpEF means that the heart is not able to fill properly with blood while it is resting so the amount of blood pumped out to the body is less than it would be if it was filling properly. The study is being done to describe the differences in how the kidneys handle protein and salt in participants with HFpEF and obesity compared to healthy persons.
The 3 groups in the trial
- Healthy Participants
Treatment: High protein and sodium meal
- Obese Participants without HFpEF
Treatment: High protein and sodium meal
- HFpEF and Obese Participants
Treatment: High protein and sodium meal
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity
- Plain-language title
- Studying kidney disease and heart failure in people with obesityGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT07052539, who can take part
- Record updated
- 4 July 2025