Compares two procedures to open narrowed neck arteries in people who had stroke symptoms
Compares surgery and stenting to treat narrowing of neck arteries after stroke symptoms.
Plain-language title generated from the registry record
Registry title: Endarterectomy Versus Stenting in Patients With Symptomatic Severe Carotid Stenosis - 2
Key facts
- Where
- Paris, FranceSee the site
Where in France
- Centre Hospitalier Sainte-AnneParis, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Centre Hospitalier St Anne
- Trial code
- NCT07054060
- Record updated
- 24 July 2025
- Original description
Carotid stenosis caused by atherosclerosis is a significant risk factor for ischemic stroke, accounting for up to 15% of all strokes and transient ischemic attacks. Randomized clinical trials (RCTs) have demonstrated the benefits of carotid endarterectomy (CEA) in reducing stroke risk in patients with severe symptomatic carotid stenosis. Carotid artery stenting (CAS) has been developed as an alternative to CEA, offering several potential advantages, such as avoiding local surgical complications. However, unlike CEA, CAS has not been compared to medical therapy in RCTs for symptomatic carotid stenosis.Read full original descriptionShow less
Endarterectomy Versus Stenting in Patients With Symptomatic Severe Carotid Stenosis - 2
Carotid stenosis caused by atherosclerosis is a significant risk factor for ischemic stroke, accounting for up to 15% of all strokes and transient ischemic attacks. Randomized clinical trials (RCTs) have demonstrated the benefits of carotid endarterectomy (CEA) in reducing stroke risk in patients with severe symptomatic carotid stenosis. Carotid artery stenting (CAS) has been developed as an alternative to CEA, offering several potential advantages, such as avoiding local surgical complications. However, unlike CEA, CAS has not been compared to medical therapy in RCTs for symptomatic carotid stenosis.
Inclusion: Patient age 18 years or over; Hemispheric or retinal transient ischemic attack or a non-disabling stroke (or retinal infarct) within 15 days before enrolment; Stenosis of 50% to 99% in the symptomatic carotid artery (NASCET method) for whom revascularisation is decided according to guidelines.
Exclusion: Previous revascularization of the symptomatic carotid stenosis; Contraindication to dual antiplatelet therapy; Percutaneaous or surgical intervention within 30 days before or after the study procedure; Nonatherosclerotic carotid disease; History of bleeding disorder; Unstable angina; Patients unwilling or unable to participate in follow-up for whatever reason; Preexisting disability (Modified Rankin Score ≥ 3); Severe tandem lesions; Contraindication to MRI; Life expectancy of less than 2 years; Stenotic lesion on arterial workup appeared as not a factor in the selection.