Brain stimulation with machine-assisted two-arm therapy for arm recovery after stroke
Tests brain stimulation plus two-arm exercise to help arm function in adults after stroke.
Plain-language title generated from the registry record
Registry title: Repetitive Transcranial Magnetic Stimulation Combined With Bimanual Therapy for Upper Limb Stroke Rehabilitation
Key facts
- Where
- Taoyuan, TaiwanSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 80 years old?
Source: NCT07054424, who can take part
Where in Taiwan
- Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital at Linkou, Taoyuan 333, TaiwanTaoyuan, TaiwanTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Chang Gung Memorial Hospital
- Trial code
- NCT07054424
- Record updated
- 11 June 2026
- Original description
The goal of this clinical trial is to evaluate whether combining repetitive transcranial magnetic stimulation (rTMS) with machine-assisted bimanual therapy (BT) can improve upper limb function in stroke patients. The participants will be individuals aged 40-80 years who have experienced a first-time ischemic or hemorrhagic stroke. The main questions it aims to answer are:Read full original descriptionShow less
Development of Repetitive Transcranial Magnetic Stimulation (rTMS) Combined With Machine-assisted Bimanual Therapy (BT) in Upper Limb Rehabilitation
The goal of this clinical trial is to evaluate whether combining repetitive transcranial magnetic stimulation (rTMS) with machine-assisted bimanual therapy (BT) can improve upper limb function in stroke patients. The participants will be individuals aged 40-80 years who have experienced a first-time ischemic or hemorrhagic stroke. The main questions it aims to answer are:
* Does the combined therapy enhance motor recovery compared to traditional rehabilitation methods? * Are changes in brain activity associated with improvements in upper limb function?
Participants will be randomly assigned to different groups and will:
* Receive rTMS stimulation on specific areas of the brain to modulate neural activity, * Perform machine-assisted bimanual exercises to promote motor skills, and * Undergo assessments before, immediately after, and during follow-up periods to measure functional improvements.
Inclusion: Age 40-80 years; First-onset stroke patients; Patients diagnosed with cerebral infarction or hemorrhage through CT or MRI; Signed informed consent form by the patient and their family; Stable physiological parameters; Stroke occurred within the last 12 months; Patients with unilateral hand function impairment caused by the stroke; Upper limb muscle tone (Modified Ashworth Scale, MAS) less than 3 points; Able to follow two-step commands.
Exclusion: Currently using medications that lower the seizure threshold; Subjects taking antidepressants who cannot discontinue the medication; A history of epilepsy or family history of epilepsy; Co-existing neurological diseases (such as multiple sclerosis, other neurodegenerative diseases, meningitis, brain abscess, or meningioma); Subjects with sleep disorders during rTMS treatment; Subjects with cerebellar stroke or brainstem stroke; Cerebral ischemic disorders resulting from traumatic brain injury; History of bleeding tendency and other conditions affecting upper limb function, such as myasthenia gravis, systemic immune neuropathy, severe epilepsy, endocrine system disorders, wearers of external or internal cardiac pacemakers, individuals with metallic implants or orthopedic devices; Co-existing severe heart, liver, kidney dysfunction, or other serious physical illnesses; Subjects with impaired consciousness who cannot cooperate with examinations or treatments, such as those with mental disorders, or those with intellectual or cognitive impairments, severe dementia; Co-existing severe liver, kidney, or hematological disorders; Skin disease (e.g., pressure ulcers, trauma, cellulitis, etc.); Presence of suicidal tendencies; Pregnant or planning to become pregnant; Subjects with uncontrollable migraines caused by elevated intracranial pressure; Transient ischemic attacks (TIAs); Presence of implanted electronic devices in the body; Special vulnerable populations.