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Studying breathing during sleep in people with lung disease

Compares sleep breathing patterns in adults with chronic lung disease, with and without sleep apnoea.

Key facts

Who runs it
University College, London
Where
London, United KingdomSee the site
Trial code
Registry title
The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease
Status
Recruiting
People taking part
120 people, planned
Started
30 Apr 2025
Planned end
30 Sept 2026
Type of study
Observational
Record updated
11 July 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with a long-term lung disease, with or without sleep-disordered breathing. People with a negative earlier sleep study can join as a comparison group.

Age
18 years or older
Sex
All sexes
Disease stage
Adults with chronic respiratory disease (COPD, asthma, interstitial lung disease, bronchiectasis), with or without sleep-disordered breathing
Earlier treatment
People who had a negative sleep study before can join as a control group

Main reasons for not taking part

  • Under 18 years of age at the time of the index study
  • Contraindications to portable monitoring
  • Cannot give informed consent

The registry criteria, word for word

Show all 7 criteriaShow less

Who can take part

  • All adult patients (≥ 18years) with chronic respiratory disease with/without SDB
  • patients who have had previously negative studies as a control group
  • Subject is able to read, understand, and sign the informed consent form
  • Willing to sleep with portable monitoring devices

Who cannot take part

  • Patients who are under 18 years of age at the time of the index study
  • Contraindications to the use of portable monitoring
  • Inability to give informed consent to take part in the study

Where in United Kingdom

  • Royal Free HospitalLondon, United KingdomContact: Nawal Alotaibi, Phd studentTaking people

About the trial

What the trial wants to find out

Research is being conducted into chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease, and bronchiectasis. The investigation specifically focuses on sleep-disordered breathing (SDB) in individuals with chronic respiratory disease. SDB encompasses a range of conditions, the most common of which is obstructive sleep apnoea. In obstructive sleep apnoea, periodic pauses in breathing (apnoea) lead to reduced blood oxygen levels. To detect these events, patients typically undergo sleep studies that involve monitoring oxygen saturation, heart rate, and respiratory patterns during sleep. When chronic respiratory disease and SDB coexist, breathing disturbances during sleep may be exacerbated.

Read full original descriptionShow less

To identify SDB, sleep studies are commonly used to assess oxygen levels, heart rate, and breathing patterns. The objective of this research is to identify differences between patients with chronic respiratory diseases who have SDB and those who do not. This will be achieved by analysing sleep study data using a novel analytical approach. The aim is to determine whether this method can yield more detailed insights into the underlying pathophysiology of these conditions.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease
Plain-language title
Studying breathing during sleep in people with lung diseaseGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
11 July 2025