Taking people in United StatesPhase 3
Tests added chemotherapy with pembrolizumab before radiation in locally advanced cervical cancer
Tests adding induction chemotherapy and pembrolizumab before chemoradiation in high-risk cervical cancer.
Plain-language title generated from the registry record
Registry title: Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer
Key facts
- Where
- Albuquerque, Alexandria, Allentown, Ankeny, Ann Arbor, Ashland, Atlanta, Augusta, Aurora, Baltimore, Basking Ridge, Bath, Bay Shore, Beachwood, Bel Air, Bellevue, Bellflower, Bethlehem, Billings, Birmingham, Boise, Boston, Brainerd, Bridgeport, Brighton, Buffalo, Burlington, Caldwell, Camden, Canton, Carmel, Cedar Rapids, Centerville, Chapel Hill, Chardon, Charleston, Charlotte, Charlottesville, Chelsea, Cheyenne, Chicago, Cincinnati, Clackamas, Cleveland, Clive, Coeur d'Alene, Columbia, Columbus, Commack, Concord, Coral Gables, Coral Springs, Corona, Crown Point, Dallas, Danbury, Danville, Dayton, Dearborn, Decatur, Deer River, Deerfield Beach, DeKalb, Des Moines, Dickson City, Doral, Duarte, Duluth, Durham, Dyer, East Stroudsburg, Easton, Effingham, Erie, Evanston, Fairfax, Falls Church, Farmington, Fayetteville, Flushing, Forest Hills, Fort Lauderdale, Fort Wayne, Fort Worth, Franklin, Fruitland, Gaffney, Gastonia, Geneva, Glen Burnie, Glenview, Greenlawn, Greensburg, Greenville, Greer, Harbor City, Harrisburg, Harrison, Hershey, Hibbing, High Point, Highlands Ranch, Hobart, Hollywood, Huntersville, Indiana, Indianapolis, Iowa City, Irvine, Jefferson Hills, Jersey City, Johnstown, Joplin, Kalamazoo, Kansas City, Kernersville, La Jolla, Lake Success, Lancaster, Lansing, Largo, Las Vegas, Lebanon, Lee's Summit, Leesburg, Lewisburg, Lexington, Little Rock, Livingston, Livonia, Long Branch, Los Angeles, Madison, Marrero, Matthews, Mattoon, Mayfield Heights, Maywood, Mechanicsburg, Mentor, Meridian, Metairie, Miami, Miami Beach, Middletown, Millville, Milwaukee, Mineola, Missoula, Monroeville, Montvale, Morgantown, Mount Kisco, Mukwonago, Munster, N. Venice, Nampa, New Brunswick, New Orleans, New Richmond, New York, Newark, Newberg, Newnan, North Miami, Norwalk, Oak Brook, Ocoee, Oconomowoc, Oklahoma City, Omaha, Orange, Oregon City, Orland Park, Orlando, Oswego, Overland Park, Panorama City, Parkersburg, Parma, Pembroke Pines, Pennington, Peoria, Philadelphia, Pittsburgh, Plantation, Pontiac, Portland, Post Falls, Providence, Quakertown, Raleigh, Rego Park, Rehoboth Beach, Richardson, Richmond, Roanoke, Rochester, Rockford, Rogers, Rolla, Royal Oak, Ruskin, Sacramento, Saint Paul, Salinas, Salt Lake City, San Diego, San Francisco, San Marcos, Sandstone, Sanford, Sarasota, Scarborough, Seattle, Seneca, Sioux Falls, Sleepy Hollow, South Pasadena, Spartanburg, Springdale, Springfield, St Louis, Staten Island, Stony Brook, Stroudsburg, Superior, Supply, Sylvania, Syracuse, Tampa, The Bronx, Toms River, Towson, Troy, Tualatin, Tulsa, Uniondale, Upland, Urbana, Valparaiso, Vancouver, Venice, Verona, Virginia, Warrenville, Waukee, Waukesha, Wesley Chapel, West Chester, Westlake, Westwood, Wexford, Wilkes-Barre, Willow Grove, Wilmington, Winston-Salem, Woodland Hills, and Zion, United StatesSee the 345 sites
- Phase
- Phase 3
Where in United States
- University of New Mexico Cancer CenterAlbuquerque, United StatesTaking people
- Inova Alexandria HospitalAlexandria, United StatesTaking people
- Lehigh Valley Hospital-Cedar CrestAllentown, United StatesTaking people
- Saint Luke's Cancer Center - AllentownAllentown, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Ankeny ClinicAnkeny, United StatesTaking people
- Trinity Health Saint Joseph Mercy Hospital Ann ArborAnn Arbor, United StatesTaking people
- University of Michigan Rogel Cancer CenterAnn Arbor, United StatesTaking people
- Duluth Clinic AshlandAshland, United StatesTaking people
- Northwest Wisconsin Cancer CenterAshland, United StatesTaking people
- Emory University Hospital MidtownAtlanta, United StatesTaking people
- Emory University Hospital/Winship Cancer InstituteAtlanta, United StatesTaking people
- Piedmont HospitalAtlanta, United StatesTaking people
- Augusta University Medical CenterAugusta, United StatesTaking people
- UCHealth University of Colorado HospitalAurora, United StatesTaking people
- Johns Hopkins University/Sidney Kimmel Cancer CenterBaltimore, United StatesTaking people
- University of Maryland/Greenebaum Cancer CenterBaltimore, United StatesTaking people
- Memorial Sloan Kettering Basking RidgeBasking Ridge, United StatesTaking people
- MaineHealth Coastal Cancer Treatment CenterBath, United StatesTaking people
- Northwell Health Imbert Cancer CenterBay Shore, United StatesTaking people
- UHHS-Chagrin Highlands Medical CenterBeachwood, United StatesTaking people
- UM Upper Chesapeake Medical CenterBel Air, United StatesTaking people
- Nebraska Medicine-BellevueBellevue, United StatesTaking people
- Kaiser Permanente-BellflowerBellflower, United StatesTaking people
- Lehigh Valley Hospital - MuhlenbergBethlehem, United StatesTaking people
- Saint Luke's University Hospital-Bethlehem CampusBethlehem, United StatesTaking people
- Billings Clinic Cancer CenterBillings, United StatesTaking people
- University of Alabama at Birmingham Cancer CenterBirmingham, United StatesTaking people
- Saint Alphonsus Cancer Care Center-BoiseBoise, United StatesTaking people
- Saint Luke's Cancer Institute - BoiseBoise, United StatesTaking people
- Beth Israel Deaconess Medical CenterBoston, United StatesTaking people
- Tufts Medical CenterBoston, United StatesTaking people
- Essentia Health Saint Joseph's Medical CenterBrainerd, United StatesTaking people
- United Hospital CenterBridgeport, United StatesTaking people
- Trinity Health Medical Center - BrightonBrighton, United StatesTaking people
- University of Michigan - Brighton Center for Specialty CareBrighton, United StatesTaking people
- Roswell Park Cancer InstituteBuffalo, United StatesTaking people
- University of Vermont and State Agricultural CollegeBurlington, United StatesTaking people
- University of Vermont Medical CenterBurlington, United StatesTaking people
- Saint Alphonsus Cancer Care Center-CaldwellCaldwell, United StatesTaking people
- Cooper Hospital University Medical CenterCamden, United StatesTaking people
- Aultman Health FoundationCanton, United StatesTaking people
- Trinity Health Medical Center - CantonCanton, United StatesTaking people
- IU Health North HospitalCarmel, United StatesTaking people
- Mercy HospitalCedar Rapids, United StatesTaking people
- Oncology Associates at Mercy Medical CenterCedar Rapids, United StatesTaking people
- Miami Valley Hospital SouthCenterville, United StatesTaking people
- UNC Lineberger Comprehensive Cancer CenterChapel Hill, United StatesTaking people
- Geauga HospitalChardon, United StatesTaking people
- Medical University of South CarolinaCharleston, United StatesTaking people
- Vandalia Health/CAMC Institute for Academic MedicineCharleston, United StatesTaking people
- Carolinas Medical Center/Levine Cancer InstituteCharlotte, United StatesTaking people
- Novant Health Presbyterian Medical CenterCharlotte, United StatesTaking people
- University of Virginia Cancer CenterCharlottesville, United StatesTaking people
- Chelsea HospitalChelsea, United StatesTaking people
- Memorial Hospital of Laramie CountyCheyenne, United StatesTaking people
- John H Stroger Jr Hospital of Cook CountyChicago, United StatesTaking people
- Northwestern UniversityChicago, United StatesTaking people
- Rush MD Anderson Cancer CenterChicago, United StatesTaking people
- University of IllinoisChicago, United StatesTaking people
- University of Cincinnati Cancer Center-UC Medical CenterCincinnati, United StatesTaking people
- Clackamas Radiation Oncology CenterClackamas, United StatesTaking people
- Case Western Reserve UniversityCleveland, United StatesTaking people
- Cleveland Clinic FoundationCleveland, United StatesTaking people
- UI Health Care Mission Cancer and Blood - West Des Moines ClinicClive, United StatesTaking people
- Kootenai Health - Coeur d'AleneCoeur d'Alene, United StatesNo longer taking part
- Central Maryland Radiation Oncology in Howard CountyColumbia, United StatesTaking people
- Ohio State University Comprehensive Cancer CenterColumbus, United StatesTaking people
- Memorial Sloan Kettering CommackCommack, United StatesTaking people
- Atrium Health Cabarrus/LCI-ConcordConcord, United StatesTaking people
- UM Sylvester Comprehensive Cancer Center at Coral GablesCoral Gables, United StatesTaking people
- UM Sylvester Comprehensive Cancer Center at Coral SpringsCoral Springs, United StatesTaking people
- City of Hope CoronaCorona, United StatesTaking people
- Northwest Cancer Center - Crown PointCrown Point, United StatesTaking people
- Parkland Memorial HospitalDallas, United StatesTaking people
- UT Southwestern/Simmons Cancer Center-DallasDallas, United StatesTaking people
- Danbury HospitalDanbury, United StatesTaking people
- Carle at The RiverfrontDanville, United StatesTaking people
- Geisinger Medical CenterDanville, United StatesTaking people
- Miami Valley HospitalDayton, United StatesTaking people
- Miami Valley Hospital NorthDayton, United StatesTaking people
- Corewell Health Dearborn HospitalDearborn, United StatesTaking people
- Cancer Care Specialists of Illinois - DecaturDecatur, United StatesTaking people
- Decatur Memorial HospitalDecatur, United StatesTaking people
- Emory Decatur HospitalDecatur, United StatesTaking people
- Essentia Health - Deer River ClinicDeer River, United StatesTaking people
- UM Sylvester Comprehensive Cancer Center at Deerfield BeachDeerfield Beach, United StatesTaking people
- Northwestern Medicine Cancer Center KishwaukeeDeKalb, United StatesTaking people
- Iowa Methodist Medical CenterDes Moines, United StatesTaking people
- Mercy Medical Center - Des MoinesDes Moines, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Des Moines ClinicDes Moines, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Laurel ClinicDes Moines, United StatesTaking people
- Geisinger Cancer Center Dickson CityDickson City, United StatesTaking people
- UM Sylvester Comprehensive Cancer Center at DoralDoral, United StatesTaking people
- City of Hope Comprehensive Cancer CenterDuarte, United StatesTaking people
- Essentia Health Cancer CenterDuluth, United StatesTaking people
- Miller-Dwan HospitalDuluth, United StatesTaking people
- Duke University Medical CenterDurham, United StatesTaking people
- Northwest Oncology LLCDyer, United StatesTaking people
- Pocono Medical CenterEast Stroudsburg, United StatesTaking people
- Saint Luke's Hospital-Anderson CampusEaston, United StatesTaking people
- University of Maryland Shore Medical Center at EastonEaston, United StatesTaking people
- Carle Physician Group-EffinghamEffingham, United StatesTaking people
- Crossroads Cancer CenterEffingham, United StatesNo longer taking part
- UPMC Hillman Cancer Center ErieErie, United StatesTaking people
- NorthShore University HealthSystem-Evanston HospitalEvanston, United StatesTaking people
- Inova Fair Oaks HospitalFairfax, United StatesTaking people
- Inova Schar Cancer InstituteFairfax, United StatesTaking people
- Inova Fairfax HospitalFalls Church, United StatesTaking people
- Farmington Health CenterFarmington, United StatesTaking people
- Highlands Oncology Group - FayettevilleFayetteville, United StatesTaking people
- Northwell Health Physician Partners at FlushingFlushing, United StatesTaking people
- Northwell Health Physicians Partners Radiation Medicine at QueensForest Hills, United StatesTaking people
- Broward Health Medical CenterFort Lauderdale, United StatesTaking people
- Parkview Regional Medical CenterFort Wayne, United StatesTaking people
- UT Southwestern/Simmons Cancer Center-Fort WorthFort Worth, United StatesTaking people
- Atrium Medical Center-Middletown Regional HospitalFranklin, United StatesTaking people
- Saint Luke's Cancer Institute - FruitlandFruitland, United StatesTaking people
- Gibbs Cancer Center-GaffneyGaffney, United StatesTaking people
- Levine Cancer Institute-GastonGastonia, United StatesTaking people
- Northwestern Medicine Cancer Center DelnorGeneva, United StatesTaking people
- UM Baltimore Washington Medical Center/Tate Cancer CenterGlen Burnie, United StatesTaking people
- NorthShore University HealthSystem-Glenbrook HospitalGlenview, United StatesTaking people
- Northwell Health Cancer Institute at HuntingtonGreenlawn, United StatesTaking people
- UPMC Cancer Centers - Arnold Palmer PavilionGreensburg, United StatesTaking people
- Miami Valley Cancer Care and InfusionGreenville, United StatesTaking people
- Gibbs Cancer Center-PelhamGreer, United StatesTaking people
- Kaiser Permanente South BayHarbor City, United StatesTaking people
- UPMC Pinnacle Cancer Center/Community Osteopathic CampusHarrisburg, United StatesTaking people
- Memorial Sloan Kettering WestchesterHarrison, United StatesTaking people
- Penn State Milton S. Hershey Medical CenterHershey, United StatesTaking people
- Essentia Health Hibbing ClinicHibbing, United StatesTaking people
- Hayworth Cancer CenterHigh Point, United StatesTaking people
- UCHealth Highlands Ranch HospitalHighlands Ranch, United StatesTaking people
- Northwest Cancer Center - HobartHobart, United StatesTaking people
- Saint Mary Medical CenterHobart, United StatesTaking people
- Memorial Regional Hospital/Joe DiMaggio Children's HospitalHollywood, United StatesTaking people
- UM Sylvester Comprehensive Cancer Center at HollywoodHollywood, United StatesTaking people
- Novant Health Cancer Institute - HuntersvilleHuntersville, United StatesTaking people
- IRMC Cancer CenterIndiana, United StatesTaking people
- Indiana University/Melvin and Bren Simon Cancer CenterIndianapolis, United StatesTaking people
- Sidney and Lois Eskenazi HospitalIndianapolis, United StatesTaking people
- University of Iowa/Holden Comprehensive Cancer CenterIowa City, United StatesTaking people
- City of Hope at Irvine LennarIrvine, United StatesTaking people
- Kaiser Permanente-IrvineIrvine, United StatesTaking people
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory CareIrvine, United StatesTaking people
- Jefferson HospitalJefferson Hills, United StatesTaking people
- Jersey City Medical CenterJersey City, United StatesTaking people
- UPMC-Johnstown/John P. Murtha Regional Cancer CenterJohnstown, United StatesTaking people
- Freeman Health SystemJoplin, United StatesTaking people
- Bronson Methodist HospitalKalamazoo, United StatesTaking people
- West Michigan Cancer CenterKalamazoo, United StatesTaking people
- University of Kansas Cancer CenterKansas City, United StatesTaking people
- University of Kansas Cancer Center - BriarcliffKansas City, United StatesTaking people
- University of Kansas Cancer Center - NorthKansas City, United StatesTaking people
- Novant Health Cancer Institute - KernersvilleKernersville, United StatesTaking people
- UC San Diego Moores Cancer CenterLa Jolla, United StatesTaking people
- Northwell Health/Center for Advanced MedicineLake Success, United StatesTaking people
- City of Hope Antelope ValleyLancaster, United StatesNo longer taking part
- University of Michigan Health - Sparrow LansingLansing, United StatesTaking people
- UM Capital Region Medical CenterLargo, United StatesTaking people
- Women's Cancer Center of NevadaLas Vegas, United StatesTaking people
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterLebanon, United StatesTaking people
- University of Kansas Cancer Center - Lee's SummitLee's Summit, United StatesTaking people
- Inova Loudoun HospitalLeesburg, United StatesTaking people
- Geisinger Medical Oncology-LewisburgLewisburg, United StatesTaking people
- University of Kentucky/Markey Cancer CenterLexington, United StatesTaking people
- University of Arkansas for Medical SciencesLittle Rock, United StatesTaking people
- Cooperman Barnabas Medical CenterLivingston, United StatesTaking people
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, United StatesTaking people
- Monmouth Medical CenterLong Branch, United StatesTaking people
- Cedars-Sinai Medical CenterLos Angeles, United StatesTaking people
- Kaiser Permanente Los Angeles Medical CenterLos Angeles, United StatesTaking people
- Kaiser Permanente West Los AngelesLos Angeles, United StatesTaking people
- University of Wisconsin Carbone Cancer Center - Eastpark Medical CenterMadison, United StatesTaking people
- University of Wisconsin Carbone Cancer Center - University HospitalMadison, United StatesTaking people
- West Jefferson Medical CenterMarrero, United StatesTaking people
- Matthews Radiation Oncology CenterMatthews, United StatesTaking people
- Carle Physician Group-Mattoon/CharlestonMattoon, United StatesTaking people
- Hillcrest Hospital Cancer CenterMayfield Heights, United StatesTaking people
- Loyola University Medical CenterMaywood, United StatesTaking people
- UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer PavilionMechanicsburg, United StatesTaking people
- UH Seidman Cancer Center at Lake Health Mentor CampusMentor, United StatesTaking people
- Saint Luke's Cancer Institute - MeridianMeridian, United StatesTaking people
- East Jefferson General HospitalMetairie, United StatesTaking people
- LSU Healthcare Network / Metairie Multi-Specialty ClinicMetairie, United StatesTaking people
- Miami Cancer InstituteMiami, United StatesTaking people
- UM Sylvester Comprehensive Cancer Center at KendallMiami, United StatesTaking people
- University of Miami Miller School of Medicine-Sylvester Cancer CenterMiami, United StatesTaking people
- Mount Sinai Medical CenterMiami Beach, United StatesTaking people
- Memorial Sloan Kettering MonmouthMiddletown, United StatesTaking people
- Beebe South Coastal Health CampusMillville, United StatesTaking people
- Medical College of WisconsinMilwaukee, United StatesTaking people
- NYU Langone Hospital - Long IslandMineola, United StatesTaking people
- Community Medical CenterMissoula, United StatesNo longer taking part
- Forbes HospitalMonroeville, United StatesTaking people
- Memorial Sloan Kettering BergenMontvale, United StatesTaking people
- West Virginia University HealthcareMorgantown, United StatesTaking people
- Northern Westchester HospitalMount Kisco, United StatesTaking people
- ProHealth D N Greenwald CenterMukwonago, United StatesTaking people
- The Community HospitalMunster, United StatesTaking people
- Women's Diagnostic Center - MunsterMunster, United StatesTaking people
- Sarasota Memorial Hospital-VeniceN. Venice, United StatesTaking people
- Saint Alphonsus Cancer Care Center-NampaNampa, United StatesTaking people
- Saint Luke's Cancer Institute - NampaNampa, United StatesTaking people
- Rutgers Cancer Institute of New JerseyNew Brunswick, United StatesTaking people
- Ochsner Baptist Medical CenterNew Orleans, United StatesTaking people
- Ochsner Medical Center JeffersonNew Orleans, United StatesTaking people
- University Medical Center New OrleansNew Orleans, United StatesTaking people
- Cancer Center of Western WisconsinNew Richmond, United StatesTaking people
- Laura and Isaac Perlmutter Cancer Center at NYU LangoneNew York, United StatesTaking people
- Lenox Hill HospitalNew York, United StatesTaking people
- Manhattan Eye Ear and Throat HospitalNew York, United StatesTaking people
- Memorial Sloan-Kettering Cancer CenterNew York, United StatesTaking people
- Mount Sinai ChelseaNew York, United StatesTaking people
- Mount Sinai HospitalNew York, United StatesTaking people
- Mount Sinai WestNew York, United StatesTaking people
- Helen F Graham Cancer CenterNewark, United StatesTaking people
- Medical Oncology Hematology Consultants PANewark, United StatesTaking people
- Rutgers New Jersey Medical SchoolNewark, United StatesTaking people
- Providence Newberg Medical CenterNewberg, United StatesTaking people
- CTCA at Southeastern Regional Medical CenterNewnan, United StatesTaking people
- University of Miami Sylvester Comprehensive Cancer Center at Sole MiaNorth Miami, United StatesTaking people
- Norwalk HospitalNorwalk, United StatesTaking people
- Northwestern Medicine Oak BrookOak Brook, United StatesTaking people
- Health CentralOcoee, United StatesTaking people
- ProHealth Oconomowoc Memorial HospitalOconomowoc, United StatesTaking people
- University of Oklahoma Health Sciences CenterOklahoma City, United StatesTaking people
- Nebraska Medicine-Village PointeOmaha, United StatesTaking people
- University of Nebraska Medical CenterOmaha, United StatesTaking people
- Nebraska Methodist HospitalOmaha, United StatesNo longer taking part
- UC Irvine Health- Chao Family Comprehensive Cancer CenterOrange, United StatesTaking people
- Providence Willamette Falls Medical CenterOregon City, United StatesTaking people
- Northwestern Medicine Orland ParkOrland Park, United StatesTaking people
- Orlando Health Cancer InstituteOrlando, United StatesTaking people
- Upstate Cancer Center Radiation Oncology at OswegoOswego, United StatesTaking people
- University of Kansas Cancer Center-Overland ParkOverland Park, United StatesTaking people
- University of Kansas Hospital-Indian Creek CampusOverland Park, United StatesTaking people
- Kaiser Permanente - Panorama CityPanorama City, United StatesTaking people
- Camden Clark Medical CenterParkersburg, United StatesTaking people
- University Hospitals Parma Medical CenterParma, United StatesTaking people
- Memorial Hospital WestPembroke Pines, United StatesTaking people
- Capital Health Medical Center-HopewellPennington, United StatesTaking people
- OSF Saint Francis Medical CenterPeoria, United StatesTaking people
- OSF Saint Francis Radiation Oncology at Peoria Cancer CenterPeoria, United StatesTaking people
- Fox Chase Cancer CenterPhiladelphia, United StatesTaking people
- Temple University HospitalPhiladelphia, United StatesTaking people
- Thomas Jefferson University HospitalPhiladelphia, United StatesTaking people
- Allegheny General HospitalPittsburgh, United StatesTaking people
- UPMC-Magee Womens HospitalPittsburgh, United StatesTaking people
- UPMC-Passavant HospitalPittsburgh, United StatesTaking people
- West Penn HospitalPittsburgh, United StatesTaking people
- UM Sylvester Comprehensive Cancer Center at PlantationPlantation, United StatesTaking people
- Trinity Health Saint Joseph Mercy Oakland HospitalPontiac, United StatesNo longer taking part
- Kaiser Permanente NorthwestPortland, United StatesTaking people
- Legacy Good Samaritan Hospital and Medical CenterPortland, United StatesTaking people
- MaineHealth Maine Medical Center - PortlandPortland, United StatesTaking people
- Oregon Health and Science UniversityPortland, United StatesTaking people
- Providence Portland Medical CenterPortland, United StatesTaking people
- Providence Saint Vincent Medical CenterPortland, United StatesTaking people
- Kootenai Clinic Cancer Services - Post FallsPost Falls, United StatesNo longer taking part
- Women and Infants HospitalProvidence, United StatesTaking people
- Saint Luke's Hospital - Upper Bucks CampusQuakertown, United StatesTaking people
- Duke Women's Cancer Care RaleighRaleigh, United StatesTaking people
- Queens Cancer CenterRego Park, United StatesTaking people
- Beebe Health CampusRehoboth Beach, United StatesTaking people
- UT Southwestern Clinical Center at Richardson/PlanoRichardson, United StatesTaking people
- VCU Massey Comprehensive Cancer CenterRichmond, United StatesTaking people
- Carilion Roanoke Memorial HospitalRoanoke, United StatesTaking people
- Mayo Clinic in RochesterRochester, United StatesTaking people
- UW Health Carbone Cancer Center RockfordRockford, United StatesTaking people
- Highlands Oncology Group - RogersRogers, United StatesTaking people
- Phelps Health Delbert Day Cancer InstituteRolla, United StatesTaking people
- Corewell Health William Beaumont University HospitalRoyal Oak, United StatesTaking people
- Moffitt Cancer Center at SouthShoreRuskin, United StatesTaking people
- Sutter Medical Center SacramentoSacramento, United StatesTaking people
- Regions HospitalSaint Paul, United StatesTaking people
- Salinas Valley MemorialSalinas, United StatesTaking people
- Huntsman Cancer Institute/University of UtahSalt Lake City, United StatesTaking people
- University of Utah Sugarhouse Health CenterSalt Lake City, United StatesTaking people
- Kaiser Permanente-San Diego ZionSan Diego, United StatesTaking people
- California Pacific Medical Center-Pacific CampusSan Francisco, United StatesTaking people
- Kaiser Permanente-San MarcosSan Marcos, United StatesTaking people
- Essentia Health SandstoneSandstone, United StatesTaking people
- MaineHealth Cancer Care Center of York CountySanford, United StatesTaking people
- Florida Cancer Specialists - Sarasota DowntownSarasota, United StatesTaking people
- FPG - Surgical Oncology Clinics Gynecologic Oncology SurgerySarasota, United StatesTaking people
- Sarasota Memorial Health Care Center at University ParkwaySarasota, United StatesTaking people
- Sarasota Memorial HospitalSarasota, United StatesTaking people
- MaineHealth Maine Medical Center- ScarboroughScarborough, United StatesTaking people
- Fred Hutchinson Cancer CenterSeattle, United StatesTaking people
- UPMC Cancer Center at UPMC NorthwestSeneca, United StatesTaking people
- Avera Cancer InstituteSioux Falls, United StatesTaking people
- Phelps Memorial Hospital CenterSleepy Hollow, United StatesTaking people
- City of Hope South PasadenaSouth Pasadena, United StatesTaking people
- Spartanburg Medical CenterSpartanburg, United StatesTaking people
- Highlands Oncology GroupSpringdale, United StatesTaking people
- Mercy Hospital SpringfieldSpringfield, United StatesTaking people
- Southern Illinois University School of MedicineSpringfield, United StatesTaking people
- Springfield ClinicSpringfield, United StatesTaking people
- Springfield Memorial HospitalSpringfield, United StatesTaking people
- Mercy Hospital Saint LouisSt Louis, United StatesTaking people
- Staten Island University HospitalStaten Island, United StatesTaking people
- Stony Brook University Medical CenterStony Brook, United StatesTaking people
- Saint Luke's Hospital - Monroe CampusStroudsburg, United StatesTaking people
- Essentia Health Saint Mary's Hospital - SuperiorSuperior, United StatesTaking people
- Novant Cancer Institute Radiation Oncology - SupplySupply, United StatesTaking people
- ProMedica Flower HospitalSylvania, United StatesTaking people
- State University of New York Upstate Medical UniversitySyracuse, United StatesTaking people
- Upstate Cancer Center at Hill Radiation OncologySyracuse, United StatesTaking people
- Moffitt Cancer CenterTampa, United StatesTaking people
- Moffitt Cancer Center - McKinley CampusTampa, United StatesTaking people
- Moffitt Cancer Center-International PlazaTampa, United StatesTaking people
- Montefiore Medical Center - Moses CampusThe Bronx, United StatesTaking people
- Montefiore Medical Center-Einstein CampusThe Bronx, United StatesTaking people
- Montefiore Medical Center-Weiler HospitalThe Bronx, United StatesTaking people
- Community Medical CenterToms River, United StatesTaking people
- UM Saint Joseph Medical CenterTowson, United StatesTaking people
- Corewell Health Beaumont Troy HospitalTroy, United StatesTaking people
- Upper Valley Medical CenterTroy, United StatesTaking people
- Legacy Meridian Park HospitalTualatin, United StatesTaking people
- Oklahoma Cancer Specialists and Research Institute-TulsaTulsa, United StatesTaking people
- Memorial Sloan Kettering NassauUniondale, United StatesTaking people
- City of Hope UplandUpland, United StatesTaking people
- Carle Cancer CenterUrbana, United StatesTaking people
- Northwest Cancer Center - ValparaisoValparaiso, United StatesTaking people
- Legacy Salmon Creek HospitalVancouver, United StatesTaking people
- Florida Cancer Specialists - Venice PinebrookVenice, United StatesTaking people
- Upstate Cancer Center at VeronaVerona, United StatesTaking people
- Essentia Health Virginia ClinicVirginia, United StatesTaking people
- Northwestern Medicine Cancer Center WarrenvilleWarrenville, United StatesTaking people
- UI Health Care Mission Cancer and Blood - Waukee ClinicWaukee, United StatesTaking people
- UW Cancer Center at ProHealth CareWaukesha, United StatesTaking people
- Moffitt Cancer Center at Wesley ChapelWesley Chapel, United StatesTaking people
- University of Cincinnati Cancer Center-West ChesterWest Chester, United StatesTaking people
- UH Seidman Cancer Center at Saint John Medical CenterWestlake, United StatesTaking people
- University of Kansas Hospital-Westwood Cancer CenterWestwood, United StatesTaking people
- Wexford Health and Wellness PavilionWexford, United StatesTaking people
- Geisinger Wyoming Valley/Henry Cancer CenterWilkes-Barre, United StatesTaking people
- Asplundh Cancer PavilionWillow Grove, United StatesTaking people
- Novant Health Cancer Institute Radiation Oncology - WilmingtonWilmington, United StatesTaking people
- Novant Health New Hanover Regional Medical CenterWilmington, United StatesTaking people
- Novant Health Forsyth Medical CenterWinston-Salem, United StatesTaking people
- Wake Forest University Health SciencesWinston-Salem, United StatesTaking people
- Kaiser Permanente-Woodland HillsWoodland Hills, United StatesTaking people
- Midwestern Regional Medical CenterZion, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Cancer Institute (NCI)
- Trial code
- NCT07061977
- Record updated
- 9 November 2026
- Original description
This phase III trial compares the addition of induction chemotherapy, with carboplatin, paclitaxel and pembrolizumab, to chemotherapy and radiation, with cisplatin and pembrolizumab followed by pembrolizumab maintenance for the treatment of patients with cervical cancer that has spread to nearby tissue or lymph nodes (locally advanced). Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of cancer cells. Paclitaxel is in a class of medications called antimicrotubule agents. It stops cancer cells from growing and dividing and may kill them. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of cancer cells. Adding induction chemotherapy to the usual treatment of chemotherapy and radiation followed by maintenance may be more effective in treating patients with high risk, locally advanced cervical cancer.Read full original descriptionShow less
A Phase III Study of Induction Pembrolizumab and Chemotherapy Followed by Chemoradiation and Pembrolizumab vs Chemoradiation and Pembrolizumab Both Followed by Pembrolizumab for High Risk Locally Advanced Cervical Cancer
This phase III trial compares the addition of induction chemotherapy, with carboplatin, paclitaxel and pembrolizumab, to chemotherapy and radiation, with cisplatin and pembrolizumab followed by pembrolizumab maintenance for the treatment of patients with cervical cancer that has spread to nearby tissue or lymph nodes (locally advanced). Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of cancer cells. Paclitaxel is in a class of medications called antimicrotubule agents. It stops cancer cells from growing and dividing and may kill them. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Cisplatin is in a class of medications known as platinum-containing compounds. It works by killing, stopping or slowing the growth of cancer cells. Adding induction chemotherapy to the usual treatment of chemotherapy and radiation followed by maintenance may be more effective in treating patients with high risk, locally advanced cervical cancer.
Inclusion: Patients must have pathologically confirmed newly diagnosed cervical cancer. Eligible pathologic types: squamous cell carcinoma, adenocarcinoma, adenosquamous cell carcinoma; Patients must have locally advanced cervical cancer (LACC) with T3 or T4 disease with or without lymph node involvement:; IIIA (T3aN0M0); IIIB (T3bN0M0); IIIC1(T3aN1M0, T3bN1M0); IIIC2 (T3aN2M0, T3bN2M0); IVA (T4aN0M0, T4aN1M0, T4aN2M0) No prior hysterectomy defined as removal of the entire uterus; NOTE: prior partial/subtotal hysterectomy for reasons other than cervical cancer are eligible to participate in the study. No plan to perform a hysterectomy as part of initial cervical cancer therapy; No paraaortic lymph node (PALN) metastases above the T12/L1 interspace; Note: Nodal status can be confirmed by imaging (CT, MRI, or PET/CT), fine needle aspirate/core biopsy, extra peritoneal biopsy, laparoscopic biopsy, or lymphadenectomy; Radiologic definition of lymph node staging:; N1:; One or more pelvic lymph nodes with short axis diameter of ≥ 15 mm (axial plane) by CT or MRI, and/or; One or more pelvic lymph nodes with short axis diameter of ≥ 10 mm and standardized uptake value maximum (SUVmax) ≥ 2.5 by fludeoxyglucose (FDG)-PET; N2:; One or more para-aortic lymph node with short axis diameter of ≥ 15 mm (axial plane) by CT or MRI, and/or; One or more para-aortic lymph node with short axis diameter of ≥ 10 mm and SUVmax ≥ 2.5 by FDG-PET; No prior definitive surgical, radiation, or systemic therapy for cervical cancer; No prior immunotherapy; No prior pelvic radiation therapy for any disease; Age ≥ 18; Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 2; Not pregnant and not nursing; Absolute neutrophil count (ANC) ≥ 1,500 cells/mm\^3; Platelets ≥ 100,000 cells/mm\^3; Hemoglobin ≥ 8 g/dl (Note: The use of transfusion or other intervention to achieve hemoglobulin [Hgb] ≥ 8 g/dl is acceptable); Creatinine clearance (CrCL) of ≥ 50 mL/min by the Cockcroft-Gault formula; Total bilirubin ≤ 1.5 x institutional upper limit of normal (ULN) (patients with known Gilbert's disease who have bilirubin level ≤ 3 x institutional ULN may be enrolled); Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3 x institutional ULN; Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better; No active infection requiring parenteral antibiotics; No live vaccine within 30 days prior to registration. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacille Calmette Guerin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines are live attenuated vaccines and are not allowed; No diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior registration; No active autoimmune disease that has required systemic treatment in past 2 years (i.e., with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed; No history of (non-infectious) pneumonitis that required steroids, or current pneumonitis; No history of allergic reaction to the study agent(s) or compounds of similar chemical or biologic composition to the study agent(s) (or any of its excipients).