NCT07064941Active, not recruiting
Effect of Exercise on Body Composition and Bone Health in Patients With Thalassemia
Effect of Aerobic Exercise Paired With Strength Conditioning on Bone Health in Patients With Thalassemia
Source: ClinicalTrials.gov · Last updated 22 Jul 2026
Brief summary (registry, in English)
The goal of this clinical trial is to determine if a weight bearing exercise intervention can improve body composition and bone health in adolescents and adults with Thalassemia. The main questions it aims to answer are: * Does participation in a 12-week weight bearing exercise intervention change total body lean mass and percentage body fat (as assessed by DXA) in adolescents and adults with Thalassemia? * Does participation in a 12-week weight bearing exercise intervention change muscle function (assessed by hand grip strength, sit to stand and vertical jump) and endurance (assessed by the 6 minute walk test) in adolescents and adults with Thalassemia? * Does participation in a 36 week weight bearing exercise intervention (30 min/day; 5x/week) change bone mineral density as assessed by DXA in adolescents and adults with Thalassemia? Researchers will compare participants' change in body composition, muscle mass, and muscle function during a "Usual Activity" period (12 weeks) with an exercise intervention (Period 1: 12 weeks) to see if exercise can improve body composition and muscle function. The intervention will then be extended an additional 24 weeks for a total of 36 weeks of exercise (Period 2) to explore the change in bone mineral density between between "Usual Activity" and "Exercise Intervention" (Period 2) in individuals with Thalassemia. During the intervention period, participants will engage in a self-directed exercise regime of either weight bearing aerobic exercise or strength training exercises (30 min/day; 5x/week).
- Status (registry)
- Active, not recruiting
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 7 Jul 2025
- Start date
- 1 Dec 2024
- Primary completion date
- 30 Dec 2026
- Lead sponsor
- University of California, San Francisco
- Diseases
- Thalassaemia
- NCT number
- NCT07064941
What you commit to
- Study type: Interventional
- Planned participants: 20
- From 1 Dec 2024 to the primary completion date, 30 Dec 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Hypogonadal, must be on replacement sex hormone therapy for min of 6 months
- Patients at risk for cardiovascular disease yet have not received a routine cardiology assessment within the previous 12 months
- Bone medication (e.g. Zometa, Prolia, Forteo) use in previous 2 years
Other illness
- Cardiac T2\* by Magnetic Resonance Imaging of \<20 ms (e.g. evidence of cardiac iron overload)
- Cognitive impairment limiting ability to understand instructions during orientation
- Other conditions known to influence bone health or body composition as determined by the investigator
Other
- Patients who self-identify as 'exercisers' e.g. routinely exercise for minimum of 45 min/day, 5x/week
- Pregnant (unable to conduct bone density measurements in pregnant females)
- Recent long bone or vertebral fracture (within the last 6 months)
Who the study is looking for
- Age: 14 - 40 years
- BMD Z-score at any skeletal site \< -1.0
- Diagnosed with thalassemia (any genotype, regardless of transfusion dependency)
- Vitamin D (25-Hydroxy) drawn within the previous 12 months \>20 ng/mL
- English speaking, able to consent
Age in the registry: 14 years to 40 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UCSF Benioff Children's Hospital Oakland Coordinator of this site? Confirm its status | Oakland | United States | Unknown status |
| University of California San Francisco Coordinator of this site? Confirm its status | Oakland | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.