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Treating Adolescent Obsessive Compulsive Disorder With Transcranial Magnetic Stimulation

Key facts

Who runs it
University of California, San Francisco
Where
San Francisco, United StatesSee the site
Trial code
Status
Recruiting
People taking part
30 people, planned
Started
1 Jun 2025
Expected to end
1 Jul 2027
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • Dorsal medial Prefrontal Cortex intermittent theta burst stimulation
  • cTBS to ROFC
Record updated
8 September 2026

Who can take part

Age
13 years to 17 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 15 criteriaShow less

Who can take part

  • outpatients
  • ages 13 - 17 years
  • meets current DSM-5 criteria for Obsessive Compulsive Disorder with screening CY-BOCS II score > 16 (moderate to severe)
  • stable on chronic psychotropic medications and/or therapy for 8 weeks prior to the study and agreeable to continue throughout the study without changes
  • participants may continue to take medications and record daily usage throughout the study
  • capacity to provide informed assent and parent or legal guardian able to provide consent
  • ability to tolerate clinical study procedures
  • successfully complete the screening forms without any contraindications

Who cannot take part

  • Psychiatric: history of schizophrenia, bipolar disorder, substance/alcohol abuse disorder, current elevated suicide risk, prior psychosurgery, prior ECT
  • Current and anticipated continued treatment with excluded medication (See prohibited list)
  • Neurologic: severe neurocognitive disorder, seizure disorder, certain structural brain lesions (e.g., intracranial mass lesions, hydrocephalus, sequelae of meningitis, frank brain injury)
  • TMS contraindications: implanted device; presence of metal in the head, including eyes and ears (excluding dental implants); certain tics; medications or systemic illness that predispose seizure risk; family history of 1st degree relative with seizure disorder
  • Subjects with an unstable physical, systemic, or metabolic disorder (e.g., unstable hypertension, malnutrition secondary to eating disorder)
  • Females who are pregnant or nursing (as determined by a questionnaire and pregnancy test)
  • Inability to complete the research protocol as determined by the Principal Investigator

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 13 and 17 years old?

Where in United States

  • University of California San FranciscoSan Francisco, United StatesContact: Starlette Khim, BATaking people

About the trial

What the trial wants to find out

This is a pilot study to examine the tolerability, safety and early efficacy of two forms of transcranial magnetic stimulation (TMS) for treating adolescents with Obsessive Compulsive Disorder (OCD) who have experienced limited improvements with usual treatments for OCD in adolescents.

Read full original descriptionShow less

The project's primary goal is to examine whether adolescents can complete 3 consecutive weeks of TMS administered 5 days per week, and to describe the type of and how common individual side effects with TMS occur in adolescents with OCD.

Participants will:

* visit the clinic every weekday for 3 weeks (15 days) to receive TMS treatments * have a brain MRI scan before TMS treatments begins and after finishing all TMS * complete questionnaires and report changes in behavior and physical symptoms

The 2 groups in the trial

  • Right Orbitofrontal TBSTreatment being tested

    continuous theta burst stimulation

    Treatment: cTBS to ROFC

  • TBS of dorsal, medial prefrontal cortexExisting treatment, for comparison

    intermittent theta burst stimulation (iTBS) will be delivered to the dmPFC

    Treatment: Dorsal medial Prefrontal Cortex intermittent theta burst stimulation

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Fit questions
Built from NCT07065669, who can take part
Record updated
8 September 2026