Brain Stimulation and Exercise Games Tested in Motor Neuron Disease
Tests brain stimulation with exercise games in adults with ALS.
Plain-language title generated from the registry record
Registry title: Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease
Key facts
- Where
- Bangkok, ThailandSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07067229, who can take part
Where in Thailand
- King Chulalongkorn Memorial hospital, The Thai Red Cross SocietyBangkok, ThailandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Chulalongkorn University
- Trial code
- NCT07067229
- Record updated
- 25 September 2025
- Original description
Motor neuron disease (MND) is a progressive neurological disorder involving degeneration of motor neurons, leading to muscle weakness, speech and swallowing difficulties, and respiratory failure. This study aims to develop a novel treatment approach combining personalized repetitive transcranial magnetic stimulation (rTMS) with mixed reality (MR) exercise-based games (exergames) to slow disease progression and improve quality of life. In this randomised controlled trial study will compare three groups: (1) rTMS with MR exercise (personalized intervention), (2) rTMS with MR exercise (standard intervention), and (3) sham rTMS with MR exercise. Outcomes will be assessed at baseline, 3 months, and 6 months post intervention. The long-term goal is to implement this approach in clinical settings to enhance care for people with MND.Read full original descriptionShow less
Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease
Motor neuron disease (MND) is a progressive neurological disorder involving degeneration of motor neurons, leading to muscle weakness, speech and swallowing difficulties, and respiratory failure. This study aims to develop a novel treatment approach combining personalized repetitive transcranial magnetic stimulation (rTMS) with mixed reality (MR) exercise-based games (exergames) to slow disease progression and improve quality of life. In this randomised controlled trial study will compare three groups: (1) rTMS with MR exercise (personalized intervention), (2) rTMS with MR exercise (standard intervention), and (3) sham rTMS with MR exercise. Outcomes will be assessed at baseline, 3 months, and 6 months post intervention. The long-term goal is to implement this approach in clinical settings to enhance care for people with MND.
Inclusion: Participants aged between 18 and 80 years; Diagnosed with any type of motor neuron disease (MND); Have mild to moderate severity, as assessed by the Sinaki-Mulder scale, with a severity level between 1 and 3.
Exclusion: History of other neurological disorders, such as stroke; Severe dementia; Use of ventilatory support.