Taking people in ThailandNo phase

Brain Stimulation and Exercise Games Tested in Motor Neuron Disease

Tests brain stimulation with exercise games in adults with ALS.

Key facts

Who runs it: Chulalongkorn University
Where: Bangkok, ThailandSee the site
Trial code: NCT07067229
Registry title: Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease
Status: Recruiting
People taking part: 100 people, planned
Started: 1 Aug 2025
Expected to end: 30 Dec 2027
Type of study: Interventional, 3 groupsOne group gets an existing treatment, for comparison.
Treatments tested: Personalized rTMS
Standard rTMS
Sham rTMS
Record updated: 25 September 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults aged 18 to 80 with any type of motor neuron disease of mild to moderate severity. It tests magnetic brain stimulation together with exercise games.

Age: 18 to 80 years
Sex: All sexes can join.
Disease stage: Any type of motor neuron disease (MND), mild to moderate, severity level between 1 and 3 on the Sinaki-Mulder scale.

Main reasons for not taking part

History of other neurological disorders, such as stroke
Use of ventilatory support
Severe dementia

The registry criteria, word for word

Show all 6 criteriaShow less

Who can take part

Participants aged between 18 and 80 years
Diagnosed with any type of motor neuron disease (MND)
Have mild to moderate severity, as assessed by the Sinaki-Mulder scale, with a severity level between 1 and 3

Who cannot take part

History of other neurological disorders, such as stroke
Severe dementia
Use of ventilatory support

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 18 and 80 years old?

Where in Thailand

King Chulalongkorn Memorial hospital, The Thai Red Cross SocietyBangkok, ThailandContact: Jakkrit Amornvit, MDTaking people

About the trial

What the trial wants to find out

Motor neuron disease (MND) is a progressive neurological disorder involving degeneration of motor neurons, leading to muscle weakness, speech and swallowing difficulties, and respiratory failure. This study aims to develop a novel treatment approach combining personalized repetitive transcranial magnetic stimulation (rTMS) with mixed reality (MR) exercise-based games (exergames) to slow disease progression and improve quality of life. In this randomised controlled trial study will compare three groups: (1) rTMS with MR exercise (personalized intervention), (2) rTMS with MR exercise (standard intervention), and (3) sham rTMS with MR exercise. Outcomes will be assessed at baseline, 3 months, and 6 months post intervention. The long-term goal is to implement this approach in clinical settings to enhance care for people with MND.

The 3 groups in the trial

Personalized intervention groupTreatment being tested
Participants will receive personalised repetitive transcranial magnetic stimulation mixed reality.
Treatment: Personalized rTMS
Standard intervention groupExisting treatment, for comparison
Participants will receive standard repetitive transcranial magnetic stimulation plus mixed reality.
Treatment: Standard rTMS
Sham groupSham treatment, for comparison
Participants will receive sham repetitive transcranial magnetic stimulation mixed reality.
Treatment: Sham rTMS