Home Brain Training for Thinking Problems From Small Brain Vessel Disease
Tests home brain training in adults with small brain vessel disease and thinking complaints.
Plain-language title generated from the registry record
Registry title: Neurophysiological and Behavioral Study of the Cognitive Deficits Associated With Cerebral Small Vessel Disease in the SHIVA Cohort. SHIVA-CogNeurophys
Key facts
- Where
- Bordeaux, FranceSee the site
Where in France
- CHU de Bordeaux, Hôpital Pellegrin, Unité NeurovasculaireBordeaux, FranceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Bordeaux
- Trial code
- NCT07068620
- Record updated
- 2 February 2026
- Original description
Cerebral small vessel disease (cSVD) is characterized by an alteration of the structure and function of small penetrating brain arteries. Highly prevalent in older individuals from the general population, it represents a leading cause of stroke and a major contributor to cognitive decline and risk of dementia.Read full original descriptionShow less
Neurophysiological and Behavioral Study of the Cognitive Deficits Associated With Cerebral Small Vessel Disease in the SHIVA Cohort - SHIVA-CogNeurophys
Cerebral small vessel disease (cSVD) is characterized by an alteration of the structure and function of small penetrating brain arteries. Highly prevalent in older individuals from the general population, it represents a leading cause of stroke and a major contributor to cognitive decline and risk of dementia.
Better detection and management of covert cSVD would have a major impact on preventing disability and costs related to stroke, cognitive impairment and dementia. The aim of the present study is to identify novel electroencephalographic (EEG) biomarkers of the cognitive deficits associated with cSVD, and how these biomarkers and cognitive performance are affected by personalized cognitive training or transcranial alternating current stimulation (tACS), a non-invasvie brain stimulation technique.
Inclusion: Patients included or previously included in the SHIVA cohort; Basic computer skills (ability to open a browser, use a mouse and keyboard); Access to a personal computer with an internet connection; Independent in Activities of Daily Living (ADL) with a score ≥ 5/6, and in Instrumental Activities of Daily Living (IADL) with a score ≥ 4/8; Informed and written consent signed by the participant and the investigating physician for this study.
Exclusion: Surgical clips, metal sutures, staples, stents; Untreated psychiatric conditions that interfere with cognitive assessments; Diagnosed attention deficit disorder with or without hyperactivity or patients who could not complete all cognitive tests required in the SHIVA cohort; Systemic diseases that cause cognitive changes, such as obesity and metabolic disorders; History of epilepsy or seizures; Heart valve or endovascular material; Age-related macular degeneration (AMD); Motor impairments preventing the use of a keyboard and mouse (e.g., motor issues related to severe hand osteoarthritis); Depressive symptoms indicated by a score of 2 to 4 on the mini Geriatric Depression Scale (mini GDS), which includes 4 items; Untreated glaucoma; Scalp sensitivity or skin lesions (dermatitis, wounds, etc.); Contraindications for the use of electrical stimulation:; Osteosynthesis material in the head or neck; Pacemaker; Implanted hearing aid; Ocular foreign bodies, shrapnel, bullets; Metalworker; Pacemaker or neurostimulator; Ventricular shunt valve; Recent exposure (< 6 months) to brain stimulation (tDCS, TMS, etc.); Ongoing participation in a clinical trial or cognitive training program.