Imaging Brain Blood Flow in Narrowed Head and Neck Arteries
Uses PET/MR scans to study brain blood flow in adults with narrowed arteries.
Plain-language title generated from the registry record
Registry title: PET/MR Multimodal Quantitative Analysis of CBF and CMRGlc in Cerebral Ischemia
Key facts
- Where
- Beijing, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07079345, who can take part
Where in China
- Xuanwu Hospitail, Capital Medical UniversityBeijing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Xuanwu Hospital, Beijing
- Trial code
- NCT07079345
- Record updated
- 20 November 2025
- Original description
Research Purpose:Read full original descriptionShow less
PET/MR Multimodal Quantitative Imaging of Cerebral Ischemia With CBF and CMRGlc Assessment in Cephalo-Carotid Atherosclerosis
Research Purpose:
This project focuses on clinical research issues in the diagnosis, treatment, and evaluation of patients with cephalic and carotid atherosclerosis. Through multimodal imaging technology, it aims to optimize non-invasive quantitative algorithm models for cerebral blood flow and cerebral metabolism, explore new imaging markers, and investigate quantitative indicators of cerebral blood flow and metabolism for the diagnosis, treatment, and evaluation of patients with cephalic and carotid atherosclerosis undergoing drug therapy or surgical treatment.
Research Design:
1. Study Type: Observational study 2. Study Subjects: In accordance with the *Chinese Clinical Management Guidelines for Cerebrovascular Diseases (2nd Edition)*, patients with cephalic and carotid atherosclerotic stenosis admitted to the department of neurosurgery will be enrolled. Data collection time points are at enrollment, 6-month follow-up, and 12-month follow-up. 3. Sample Size: 200 patients with cephalic and carotid atherosclerotic stenosis. 4. Observation Indicators: Distribution patterns of cerebral blood flow and metabolic reduction areas in patients; correlation analysis between blood flow, metabolic values and clinical scores. 5. Statistical Analysis Methods: Statistical analysis will be performed using Statistical Package for the Social Sciences (SPSS) version 21.0. All statistical results will be expressed as mean ± standard deviation. First, the Shapiro-Wilk test will be used to assess normal distribution. Under the premise of normal distribution, paired t-test will be used to compare blood flow and metabolic values between the lesion area and the contralateral area of patients, as well as to compare changes in blood flow and metabolism of patients at different time points. Pearson correlation analysis will be used to analyze the relationship between blood flow/metabolic parameters and clinical neurological function scores. The Mann-Whitney U test will be used to analyze variables with non-normal distribution. A P value < 0.05 will be considered statistically significant.
Inclusion: Angiography diagnosed unilateral anterior circulation head carotid artery stenosis, the diameter of the tube was reduced by >70%, and the contralateral anterior circulation and bilateral posterior circulation did not exceed the stenosis of >50% of the diameter reduction; Must have had a transient ischemic attack or ischemic stroke within the area of the diseased vessel within the past 12 months, with the most recent onset being more than 3 weeks; MRI showed no new infarct lesions in the skull; There is no infarct lesion in the previous pontine area; Research participants and informants can complete relevant examinations and follow-ups; Informed consent signed by the study participant or his/her authorized representative.
Exclusion: Presence of other neurological diseases that can cause brain dysfunction (such as depression, brain tumor, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal pressure hydrocephalus, etc.); Presence of other systemic diseases that can cause cognitive impairment, such as hepatic insufficiency, renal insufficiency, thyroid dysfunction, severe anemia, folic acid and vitamin B12 deficiency, specific infections (such as syphilis, HIV), alcohol and drug abuse, etc; Presence of other known diseases that may cause cognitive impairmentPresence of other known diseases that may cause cognitive impairment; Individuals with severe visual or hearing impairment, claustrophobia, or other conditions that prevent cooperation with MRI examination; Individuals suffering from diseases that make it impossible to cooperate with cognitive examinations; Poor image quality caused by head movement or other reasons during scanning; Refusal to sign the informed consent form at baseline.