Tests AZD0120 cell therapy in adults with relapsed AL amyloidosis
Tests AZD0120, a modified immune cell therapy, in adults with AL amyloidosis.
Plain-language title generated from the registry record
Registry title: A Phase 1b/2 Study of CAR T Cell Therapy Targeting CD19 and BCMA in Participants With Relapsed or Refractory AL Amyloidosis.
Key facts
- Where
- Calgary and Toronto, CanadaSee the 2 sites
- Phase
- Phase 1/2
Where in Canada
- CalgaryCalgary, CanadaNo longer taking part
- TorontoToronto, CanadaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Alexion Pharmaceuticals, Inc.
- Trial code
- NCT07081646
- Record updated
- 2 July 2026
- Original description
Open-label Phase 1b/2 study with primary objective of this study is to evaluate the safety, tolerability and efficacy of AZD0120 in participants with light chain (AL) amyloidosis.Read full original descriptionShow less
A Phase 1b/2 Study of AZD0120 (Also Known as GC012F), a Chimeric Antigen Receptor T Cell Therapy Targeting CD19 and B Cell Maturation Antigen in Participants With Relapsed or Refractory AL Amyloidosis.
Open-label Phase 1b/2 study with primary objective of this study is to evaluate the safety, tolerability and efficacy of AZD0120 in participants with light chain (AL) amyloidosis.
Inclusion: Confirmed histopathological diagnosis of AL amyloidosis; One or more organs currently or historically impacted by AL amyloidosis according to consensus guidelines; Measurable hematologic disease: dFLC > 20 mg/L or serum M-protein > 5g/L; Relapsed or refractory disease with a need for additional therapy after at least 1 line of anti-plasma cell-directed therapy; ECOG performance status of 0 to 2; Must be able and willing to adhere to the study visit schedule and other protocol requirements; Women of child-bearing potential (WCBP) must have a negative serum and/or urine pregnancy test result prior to treatment. All sexually active WCBP and all sexually active male subjects must agree to use highly effective methods of birth control throughout the study.
Exclusion: Prior therapies:; CAR T cell therapy directed at any target; Prior BCMA-targeting therapy; Prior treatment with any FDA approved or investigational T cell engaging therapies (including T cell-directed bispecific or trispecific therapies) at any target within the last 6 months; Toxicity from previous anti-cancer or anti-PC-directed therapy did not resolve to baseline levels or to Grade 1 or less except for alopecia or peripheral neuropathy; Extensive GI involvement with evidence of active GI bleeding/risk of bleeding as determined by Investigator; Have any other form of amyloidosis other than AL amyloidosis; Mayo Stage IIIb AL amyloidosis; Oxygen saturation < 95% on room air; Systolic blood pressure <100mmHg; NYHA class III or IV; Active plasma cell leukemia at the time of screening; Symptomatic multiple myeloma (defined as clonal bone marrow plasma cells ≥10% plus at least one myeloma-defining event per IMWG 2014).