Tests vitamin D3 effect on heart nerve function in men with epilepsy
Tests vitamin D3 supplements in men with epilepsy and low vitamin D levels.
Plain-language title generated from the registry record
Registry title: Effect of Vitamin D3 Supplementation on Cardiac Autonomic Nerve Function in Male Epileptic Patients With Hypovitaminosis D
Key facts
- Where
- Dhaka, BangladeshSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 20 and 40 years old?
Source: NCT07085598, who can take part
Where in Bangladesh
- Bangladesh Medical UniversityDhaka, BangladeshTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Bangladesh Medical University
- Trial code
- NCT07085598
- Record updated
- 25 July 2025
- Original description
The goal of this clinical trial is to see the effect of vitamin D3 supplementation on cardiac autonomic nerve function in male epileptic patients with hypovitaminosis D that weather vitamin D improves heart rate variability or not. The main questions it aims to answer are:Read full original descriptionShow less
Effect of Vitamin D3 Supplementation on Cardiac Autonomic Nerve Function in Male Epileptic Patients With Hypovitaminosis D
The goal of this clinical trial is to see the effect of vitamin D3 supplementation on cardiac autonomic nerve function in male epileptic patients with hypovitaminosis D that weather vitamin D improves heart rate variability or not. The main questions it aims to answer are:
1. Does vitamin D improves cardiac autonomic tone in male epileptic patients? 2. Does vitamin D improves heart rate variability in male epileptic patients?
It is a self control trial. Participants will:
1. undergo through baseline HRV testing 2. start to take vitamin D3 50000 IU once in a week for 8 weeks
b) visit the university after 8 weeks for post interventional HRV testing . Researcher will compare the pre test and post test value of HRV testing.
Inclusion: • Diagnosed male patients with Epilepsy by neurologist from the OPD of Department of Neurology by taking proper history of at least two unprovoked (or reflex) seizures occuring > 24 hours apart, from patients and eye witnesses; Having hypovitaminosis D (serum vitamin D3 level <30 ng/ml); Age: 20-40 years; Sex: Male; BMI : 18.5-24.9 kg/m2; Taking antiepileptic drug for 6 months to 2 years ( Enzyme inducer AEDs, e.g. Carbamazepine, Phenytoin, Phenobarbital); Without medication that affect central nervous system other than antiepileptic drugs (AEDs).
Exclusion: • Epileptic patients taking Sodium valproate, oxcarbazepine, Topiramate, Lamotrigine, Levetiracetam; Patient having absence seizure; Alcoholic; Smoker; Patients taking following drugs will be excluded-; Anti-diabetic drugs; Antioxidant vitamin supplements; Antihypertensive drug; Anti-arrhythmic drug; Lipid lowering medications; Sedatives; Patients having known hypersensitivity to vitamin D3; All patients with the history of or currently suffering from following diseases \& condition will be excluded-; Cardiovascular disorders (Myocardial infarction, coronary heart disease, cardiac arrhythmia, CCF); Other neurological disorders (Migraine, stroke); Respiratory disorders (Bronchial asthma, COPD); Renal insufficiency (S. Creatinine > 1.5 mg/dl, Acute or chronic kidney disease); Endocrine disease (Diabetes mellitus, Thyroid disorders- hypothyroidism, hyperthyroidism); Arthritis (rheumatoid arthritis); Liver diseases; Neoplastic disease; Psychiatric disorder (schizophrenia, bipolar disorder); Current use of iron, zinc, calcium, magnesium and multivitamin supplementation; Already performing yoga or breathing exercise; Patients with hypercalcemia.