Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy
Key facts
- Who runs it
- Mayo Clinic
- Where
- Jacksonville, United StatesSee the siteAlso in 2 other countries, 2 sites
- Trial code
- Status
- Not yet recruiting
- People taking part
- 100 people, planned
- Starts
- 1 Dec 2026
- Expected to end
- 1 Dec 2027
- Type of study
- Observational, 2 groups
- Treatments tested
- Observation
- Record updated
- 7 January 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Age > or = 18 years old
- Patients willing to participate and provide an informed consent
- Patients undergoing elective craniotomy for cerebral aneurysm clipping
- Patients on chronic low-dose (75-100 mg) aspirin daily (aspirin group) or not on aspirin therapy for at least 7 days (control group) preoperatively
Who cannot take part
- Use of other antiplatelet or anticoagulant medications within 7 days prior to surgery
- Known bleeding disorders (e.g. hemophilia, thrombocytopenia)
- History of intracranial hemorrhage unrelated to aneurysm
- Emergency craniotomy
- Inability to provide informed consent
Where in United States
Also in 2 other countries, 2 sites
- Mayo Clinic FloridaJacksonville, United StatesContact: Shaun Gruenbaum, MD, PhDNo longer taking part
About the trial
What the trial wants to find out
This study is looking at how taking aspirin regularly affects bleeding during and after brain surgery. Specifically, it focuses on patients who are having elective surgery to clip a brain aneurysm.
Read full original descriptionShow less
Aspirin is commonly used to prevent heart attacks and strokes, but it can also increase the risk of bleeding. Doctors often face a tough decision: should patients stop taking aspirin before surgery to reduce bleeding risk, or continue it to prevent blood clots?
To help answer this question, researchers will observe 100 patients, some who take aspirin regularly and some who don't, at hospitals in the U.S., Russia, and Italy. They will not change any treatments but will collect information about bleeding during surgery, blood test results, and CT scans after surgery.
The goal is to better understand the risks of continuing aspirin and to help doctors make safer decisions for future patients.
The 2 groups in the trial
- Chronic aspirin
Patients on chronic aspirin
Treatment: Observation
- No aspirin
Patients who are not on aspirin
Treatment: Observation
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Assessing Surgical Perioperative rIsk in Patients on chRonic aspIrN Therapy Undergoing Elective Craniotomy for Aneurysm Clipping: a Prospective Multi-center Observational Study (ASPIRIN)
- Record updated
- 7 January 2026