Tests a 40 Hz sound device in older adults with memory decline
Tests a sound device in older adults with memory problems or mild dementia.
Plain-language title generated from the registry record
Registry title: Efficacy of Gamma Auditory Stimulation for Cognitive Decline in Older Adults (Study 1)
Key facts
- Where
- Taoyuan, TaiwanSee the site
Where in Taiwan
- Chang Gung UniversityTaoyuan, TaiwanTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Chang Gung Memorial Hospital
- Trial code
- NCT07087951
- Record updated
- 17 August 2026
- Original description
Animal studies have shown that 40 Hz auditory stimulation alone can improve spatial memory and reduce Aβ deposition. However, human studies using 40 Hz auditory stimulation alone remain limited. Therefore, this study will use a randomized, double-blind, placebo-controlled design to investigate the effects of 40 Hz auditory stimulation on cognitive function, EEG activity, sleep quality, and quality of life in older adults with mild cognitive impairment (MCI) or mild dementia.Read full original descriptionShow less
Development and Validation of an Innovative Gamma Auditory Stimulation System for Older Adults With Cognitive Decline: A Randomized, Double-blind, Placebo-controlled Study (Study 1)
Animal studies have shown that 40 Hz auditory stimulation alone can improve spatial memory and reduce Aβ deposition. However, human studies using 40 Hz auditory stimulation alone remain limited. Therefore, this study will use a randomized, double-blind, placebo-controlled design to investigate the effects of 40 Hz auditory stimulation on cognitive function, EEG activity, sleep quality, and quality of life in older adults with mild cognitive impairment (MCI) or mild dementia.
Inclusion: Age over 60 years old; MMSE≤ 24; CDR scores of 0.5 and 1; Voluntary to sign the Informed Consent Form.
Exclusion: Drug or alcohol addictions; Diagnosis of other psychiatric or neurological disorders; Serious heart, liver or kidney disorders, and visual, auditory or motor impairments interfering with neuropsychological tests; History of clinical stroke, major depressive disorder or dysthymic disorder according to the DSM-5.