Blood and Urine Markers for Kidney Injury After Kidney Removal Surgery
Studies new markers that may predict kidney injury in adults having radical nephrectomy.
Plain-language title generated from the registry record
Registry title: Novel Biomarkers and Postoperative Kidney Injury in Radical Nephrectomy
Key facts
- Where
- Beijing, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who are about to have one kidney removed (radical nephrectomy). It studies new blood and urine markers that may predict kidney injury after surgery.
- Age
- 18 years or older
- Sex
- All sexes
- Disease stage
- Planned surgery to remove one kidney (unilateral radical nephrectomy).
Main reasons for not taking part
- Only one kidney (solitary kidney)
- Chronic kidney disease stage G4 or G5 (GFR <30 mL/min/1.73m²) before surgery
- Tumor growing into the vena cava that needs thrombectomy
- Other conditions the investigator considers unsuitable for the study
Read by machine on 9 November 2026.
Where in China
- Department of Anesthesiology and Critical Care Medicine, Peking University First HospitalBeijing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Peking University First Hospital
- Trial code
- NCT07088874
- Record updated
- 8 September 2025
- Original description
The incidence of acute kidney injury (AKI) after radical nephrectomy exceeds 40%. Currently, the KDIGO criteria are the recognized diagnostic standard for AKI. These criteria primarily use serum creatinine and urine output as key indicators, but both parameters have certain limitations, such as delayed response, insensitivity, and inaccuracy. This study aims to simultaneously monitor perioperative novel renal damaging, stressful, and functional biomarkers in patients undergoing radical nephrectomy, and to investigate their predictive value for AKI and postoperative 1-year chronic kidney disease (CKD).Read full original descriptionShow less
Novel Biomarkers to Predict Acute Kidney Injury and Chronic Kidney Disease After Radical Nephrectomy: an Exploratory Prospective Cohort Study
The incidence of acute kidney injury (AKI) after radical nephrectomy exceeds 40%. Currently, the KDIGO criteria are the recognized diagnostic standard for AKI. These criteria primarily use serum creatinine and urine output as key indicators, but both parameters have certain limitations, such as delayed response, insensitivity, and inaccuracy. This study aims to simultaneously monitor perioperative novel renal damaging, stressful, and functional biomarkers in patients undergoing radical nephrectomy, and to investigate their predictive value for AKI and postoperative 1-year chronic kidney disease (CKD).
Inclusion: Age ≥18 years; Scheduled to undergo unilateral radical nephrectomy.
Exclusion: Other conditions deemed by the investigator as unsuitable for participation in this study; Preoperative diagnosis of chronic kidney disease stages G4 or G5 (GFR <30 mL/min/1.73m²); Solitary kidney; Tumor invasion of the vena cava requiring thrombectomy.