The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery
Key facts
- Who runs it
- King Abdullah International Medical Research Center
- Where
- Riyadh, Saudi ArabiaSee the site
- Trial code
- Status
- Recruiting
- Phase
- Phase 4
- People taking part
- 80 people, planned
- Started
- 15 Jul 2025
- Expected to end
- 24 Jun 2027
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- low-dose epinephrine and tranexamic acid
- Tranexamic Acid (TXA) treatment
- Record updated
- 28 July 2025
Who can take part
- Age
- 18 years to 70 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 14 criteriaShow less
Who can take part
- Patients undergoing knee joint arthroplasty
- Saudi and Non-Saudi Patient
- Patients who have Complete medical record
Who cannot take part
- End stage renal disease
- History of cerebrovascular accident or myocardial infarction in past 12 months
- History of Heart failure
- History of arrhythmia
- History of pheochromocytoma, thyrotoxicosis and glaucoma
- History of Deep venous thrombosis or pulmonary embolism
- Allergy to epinephrine or tranexamic acid
- Liver cirrhosis
- Coagulopathy
- Pre-operative Hgb <10 5
- Pregnancy or breast feeding
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Where in Saudi Arabia
- King Abdulaziz Medical City, Ministry of National Guard - Health AffairsRiyadh, Saudi ArabiaContact: Dr. Turki AlthunayanTaking people
About the trial
What the trial wants to find out
The aim of this clinical trial is to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative blood loss, thromboembolic complications, and hospitalization duration in patients undergoing knee joint arthroplasty.
Read full original descriptionShow less
Also aim to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative thromboembolic complications, and hospitalization duration
The 2 groups in the trial
- Epinephrine + Tranexamic Acid GroupTreatment being tested
The experimental group will receive both epinephrine and tranexamic acid
Treatment: low-dose epinephrine and tranexamic acid
- Tranexamic Acid GroupExisting treatment, for comparison
The comparator group will receive only tranexamic acid
Treatment: Tranexamic Acid (TXA) treatment
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Fit questions
- Built from NCT07089251, who can take part
- Record updated
- 28 July 2025