Tests a strength training program in people with Parkinson's disease
Tests a 12-week strength training program in adults with Parkinson's disease.
Plain-language title generated from the registry record
Registry title: Evaluation of Functional and Biochemical Effectiveness of a Strength Training Protocol in Parkinson's Disease
Key facts
- Where
- Madrid, SpainSee the site
Where in Spain
- Universidad VillanuevaMadrid, SpainNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Universidad Villanueva
- Trial code
- NCT07095400
- Record updated
- 31 July 2025
- Original description
Parkinson's Disease (PD) is a complex neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, which results in a range of motor symptoms such as tremor, rigidity, and bradykinesia, as well as non-motor symptoms including anxiety, depression, and cognitive decline. Strength training has emerged as a promising intervention to improve motor function and influence biochemical markers associated with oxidative stress and neurodegeneration. This study aims to evaluate the effectiveness of a structured strength training protocol over 12 weeks in improving both functional and biochemical outcomes in patients with PD.Read full original descriptionShow less
Evaluation of Functional and Biochemical Effectiveness of a Strength Training Protocol in Parkinson's Disease
Parkinson's Disease (PD) is a complex neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons, which results in a range of motor symptoms such as tremor, rigidity, and bradykinesia, as well as non-motor symptoms including anxiety, depression, and cognitive decline. Strength training has emerged as a promising intervention to improve motor function and influence biochemical markers associated with oxidative stress and neurodegeneration. This study aims to evaluate the effectiveness of a structured strength training protocol over 12 weeks in improving both functional and biochemical outcomes in patients with PD.
Inclusion: Patients diagnosed with PD who meet the modified diagnostic criteria of the UK Brain Bank; Patients in stage II or III of the Hoehn and Yahr Scale; A score greater than 60% on the Schwab and England Functional Scale; Patients whose motor response to pharmacological treatment is stable or slightly fluctuating and who are not receiving any specific strength training rehabilitation treatment at the time of the study.
Exclusion: Diagnosis of a condition other than PD; Significant comorbidities and/or severe systemic diseases that would prevent participation in exercise (e.g., recent surgery, cardiac instability, anemia, hepatosis, pulmonary disorders, chronic renal failure, or severe mental disorders); Inability to actively understand instructions and cooperate in the tasks given, based on a score <24 on the Mini-Mental State Examination (MMSE); Refusal to participate in the study; Stages I, IV, or V of the Hoehn and Yahr Scale.