Urine-guided diuretic dosing for fluid removal in acute heart failure
Tests a urine-based diuretic dosing tool in adults hospitalized with acute heart failure.
Plain-language title generated from the registry record
Registry title: Simple Urine Composition-based Personalized Algorithm for Effective Congestion Relief in Decompensated Heart Failure
Key facts
- Where
- Wroclaw, PolandSee the site
Where in Poland
- Wroclaw Medical UniversityWroclaw, PolandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Wroclaw Medical University
- Trial code
- NCT07099885
- Record updated
- 12 August 2025
- Original description
The aim of this study is to evaluate the effectiveness of loop diuretic adaptative algorithm that is based on machine learning, urine output prediction tool, in decongestion of acute heart failure patients.Read full original descriptionShow less
Simple Urine Composition-based Personalized Algorithm for Effective Congestion Relief in Decompensated Heart Failure
The aim of this study is to evaluate the effectiveness of loop diuretic adaptative algorithm that is based on machine learning, urine output prediction tool, in decongestion of acute heart failure patients.
A total of 90 patients will be enrolled in the study. Of these, 45 will be assigned to the algorithm-based intervention group, while the remaining 45 will serve as the control group. In the control group, all decisions regarding diuretic therapy will be made solely by the attending physician, without the use of the algorithm.
Patients will receive intravenous furosemide, with the initial dose determined by the attending physician. Two hours after administration of the diuretic, a spot urine sample will be collected to measure sodium and creatinine concentrations. Based on these values, the 6-hour urine output will be estimated using the machine learning, urine output prediction tool (http://diuresis.umw.edu.pl). This estimate will guide the diuretic therapy plan for the first 24 hours of hospitalization. On the second day, the procedure will be repeated using the same methodology.
Inclusion: Adult patients over 18 years of age who provide informed consent; Ability to enroll in the study within the first 24 hours of hospitalization; Primary reason for hospitalization is acute heart failure with signs of congestion (at least moderate lower extremity edema); NT-proBNP > 1500 pg/ml; Anticipated need for diuretic therapy for at least 48 hours from the time of study enrollment.
Exclusion: End-stage kidney disease requiring renal replacement therapy; Active infection requiring intravenous antibiotic therapy; Hemodynamic instability requiring inotropic support.