Tests replacing red meat with other proteins in chronic kidney disease
Tests swapping red meat for other protein foods in adults with chronic kidney disease.
Plain-language title generated from the registry record
Registry title: Effects of Replacing High Protein Foods in People With Chronic Kidney Disease
Key facts
- Where
- West Lafayette, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 70 years old?
Source: NCT07105670, who can take part
Where in United States
- Purdue UniversityWest Lafayette, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Indiana University
- Trial code
- NCT07105670
- Record updated
- 9 November 2026
- Original description
The goal of this crossover clinical trial is to explore the effects of red meat intake on serum and fractional urinary excretion of uremic toxins including trimethylamine N-oxide in people with chronic kidney disease.Read full original descriptionShow less
The Effects of Replacing Red Meat With Alternative Protein Sources on Gut-Derived Metabolites in People With Chronic Kidney Disease
The goal of this crossover clinical trial is to explore the effects of red meat intake on serum and fractional urinary excretion of uremic toxins including trimethylamine N-oxide in people with chronic kidney disease.
Inclusion: Age 40-70 years; Male or postmenopausal female; Stage 3 CKD (eGFR between 30-59ml/min/1.73m\^2 by the CKD-EPI equation (without race correction)); If eGFR is greater than or equal to 45ml/min/1.73m\^2 then albuminuria must be greater than 300mg/g creatinine by spot urine; Willing to consume controlled diet for duration of the study; Willing to collect fecal samples at home.
Exclusion: Treatment with metformin or insulin within previous three months; Blood pressure greater than 150/100 mmHg from chart of home on at least two occasions in prior month (can be inclusive of screening visit); Cancer or received cancer treatment in the last year (except basal cell carcinoma); Prior bariatric surgery (i.e. gastric bypass, sleeve gastrectomy) or restrictive bariatric surgery (i.e. adjustable gastric band); Treatment with immunosuppressive medications in the past six months or more than one week of treatment with prednisone greater than 10mg per day in the past three months (or equivalent steroid dose of non-prednisone steroids); Change in cardiovascular and/or hypertension medication in the last 30 days; History of major gastrointestinal disease (e.g. inflammatory bowel disease, uncontrolled irritable bowel syndrome, C. difficile chronic infection, celiac disease, diverticulitis, stomach or duodenal ulcers); Known HIV disease; Known food allergy that would influence the ability to consume the study diets; History of hyperkalemia defined as greater than 5.5mmol/L on at least two occasions; Other medical conditions or concerns at the discretion of the investigators; Hemoglobin A1c greater than 7% within previous six months; Hospitalization in the last two months; Significant recent unintentional weight loss (5% of weight over past three months); Recent antibiotic use defined as a single course of antibiotics within the past three months or two or more courses within the past six months.