Heart rhythm problems in emergency patients with a non-ST elevation heart attack
Observes how often serious heart rhythm problems occur in adults with a heart attack.
Plain-language title generated from the registry record
Registry title: Occurrence of Severe Cardiac Rhythm and Conduction Disturbances in Emergency Department Patients With Non-ST Elevation Acute Coronary Syndrome
Key facts
- Where
- Colmar, Haguenau, Mulhouse, Nancy, Poitiers, Pont-à-Mousson, Reims, Séléstat, Strasbourg, and Toul, FranceSee the 10 sites
Where in France
- Hôpital Louis PasteurColmar, FranceNo longer taking part
- Centre Hospitalier de HaguenauHaguenau, FranceNo longer taking part
- Hôpital Emilie MullerMulhouse, FranceNo longer taking part
- CHRU de NancyNancy, FranceNo longer taking part
- CHU de Poitiers - La MiletriePoitiers, FranceNo longer taking part
- Centre Hospitalier de Pont-à-MoussonPont-à-Mousson, FranceNo longer taking part
- Hôpital Maison BlancheReims, FranceNo longer taking part
- Centre Hospitalier de SélestatSéléstat, FranceNo longer taking part
- Hôpitaux Universitaires de Strasbourg (NHC)Strasbourg, FranceNo longer taking part
- Centre Hospitalier de Toul Saint-CharlesToul, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Strasbourg, France
- Trial code
- NCT07112547
- Record updated
- 8 August 2025
- Original description
Cardiovascular diseases are the leading cause of death worldwide. Among them, coronary artery disease-especially in its acute form, known as acute coronary syndrome (ACS)-is the most frequent cause of cardiovascular death. There are two main types of ACS: ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation ACS (NSTE-ACS). While the occurrence of serious heart rhythm and conduction disturbances is well established in STEMI, these complications are believed to be much less frequent in NSTE-ACS. However, their actual frequency in this population remains unclear due to limited studies, especially in emergency settings.Read full original descriptionShow less
Occurrence of Severe Cardiac Rhythm and Conduction Disturbances in Emergency Department Patients With Non-ST Elevation Acute Coronary Syndrome
Cardiovascular diseases are the leading cause of death worldwide. Among them, coronary artery disease-especially in its acute form, known as acute coronary syndrome (ACS)-is the most frequent cause of cardiovascular death. There are two main types of ACS: ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation ACS (NSTE-ACS). While the occurrence of serious heart rhythm and conduction disturbances is well established in STEMI, these complications are believed to be much less frequent in NSTE-ACS. However, their actual frequency in this population remains unclear due to limited studies, especially in emergency settings.
The main purpose of this study is to estimate the frequency of serious rhythm and conduction disorders in patients presenting with NSTE-ACS in emergency departments. The hypothesis is that these events are rare in this population and may not justify routine continuous cardiac monitoring for all such patients, as currently recommended.
Secondary objectives include identifying risk factors for these complications, estimating their frequency during hospitalization, assessing the frequency of minor rhythm and conduction disorders, evaluating care times and patient flow in emergency departments, and assessing patient outcomes up to 30 days-including hospitalizations, length of stay, discharge disposition, all-cause mortality, and the occurrence of five major adverse cardiovascular events (5-point MACE).
Inclusion: Adult (≥ 18 years old) patient admitted to the emergency department; Able to understand the information provided; Diagnosis of non-ST segment elevation ACS established according to the lastest guidelines from the European Society of Cardiology and the 4th Universal Definition of myocardial infarction; No objection to participation in the study after receiving appropriate information.
Exclusion: Patient with cognitive impairment; Myocardial injury and/or symptoms attributable to Takotsubo syndrome, myocarditis, pericarditis, or acute heart failure; Clinical evidence suggestive of type 2 myocardial infarction, including acute anemia with hemoglobin < 10 g/dL, sepsis, acute hypoxemic respiratory failure; Patients subject to legal protection.