Comparison of SVF Injection With and Without Microfracture in Moderate Knee Osteoarthritis
Key facts
- Who runs it
- Istanbul University
- Where
- Türkiye1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 50 people enrolled
- Started
- 2 Feb 2023
- Ended
- 3 May 2025
- Type of study
- Interventional, 2 groups
- Treatments tested
- Arthroscopic Microfracture Combined with Autologous SVF Injection
- Arthroscopic Debridement Followed by Autologous SVF Injection
- Record updated
- 22 September 2025
Who can take part
- Age
- 49 years to 71 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 7 criteriaShow less
Who can take part
- Patients with stage II-III osteoarthritis of the knee
- Patients with a mechanical axis deviation not exceeding 15 mm on the anteroposterior orthoroentgenogram x-ray
Who cannot take part
- Patients with a history of intra-articular injections within the last 6 months
- Patients with a history of knee joint surgery
- Patients with deformities on anteroposterior and lateral x-ray examinations
- Patients with a BMI greater than 35 kg/m2
- Patients diagnosed with secondary gonarthrosis (Rheumatoid arthritis, secondary to trauma)
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
This prospective, randomized controlled clinical trial aims to evaluate the clinical and radiological effects of combining stromal vascular fraction (SVF) therapy with arthroscopic microfracture in patients with knee osteoarthritis. A total of 50 patients with symptomatic gonarthrosis were randomly assigned to either receive arthroscopic debridement and intra-articular SVF injection alone or SVF injection combined with arthroscopic debridement, microfracture. The primary outcome measures include changes in VAS, WOMAC, and Lysholm scores at 3, 6, 12, and 24 months. Radiological assessment was performed using the Whole-Organ Magnetic Resonance Imaging Score (WORMS) system. The study hypothesis is that the combination therapy will result in superior clinical and cartilage regeneration outcomes compared to SVF treatment alone.
The 2 groups in the trial
- Microfracture Plus SVF GroupTreatment being tested
Participants underwent arthroscopic debridement and microfracture, followed by intra-articular injection of autologous stromal vascular fraction (SVF) derived from adipose tissue.
Treatment: Arthroscopic Microfracture Combined with Autologous SVF Injection
- SVF Only GroupTreatment being tested
Participants underwent only arthroscopic debridement. Following this, autologous SVF derived from adipose tissue was injected intra-articularly, without performing microfracture.
Treatment: Arthroscopic Debridement Followed by Autologous SVF Injection
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Effect of Arthroscopic Microfracture Combined With Stromal Vascular Fraction Therapy on Clinical and Radiological Outcomes in Gonarthrosis: A Prospective Randomized Controlled Trial
- Record updated
- 22 September 2025