Tests green propolis capsules for fatty liver disease in adults
Tests Taiwanese green propolis capsules against placebo in adults with fatty liver disease.
Plain-language title generated from the registry record
Registry title: Study on the Function of Taiwan Green Propolis in Reducing Blood Lipids and Body Fat in Sub-healthy Groups: MASLD
Key facts
- Where
- Chiayi City, TaiwanSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07114926, who can take part
Where in Taiwan
- Buddhist Tzu Chi Medical Foundation, Dalin Tzu Chi HospitalChiayi City, TaiwanNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Kuo,HSIN-YU
- Trial code
- NCT07114926
- Record updated
- 11 August 2025
- Original description
This study investigates the effectiveness of Taiwanese green propolis in reducing blood lipids and body fat in sub-healthy individuals. The study design follows a parallel, double-blind, randomized assignment approach, dividing participants into an experimental group (propolis) and a control group (placebo). Researchers explained the study plan to participants, and after obtaining signed informed consent, participants were randomly assigned using a web-based program that generated random serial numbers. The randomization was stratified by gender (male-to-female ratio of 1:1) and physiological age groups (maturity, middle age, menopause, post-menopause, and old age). Serial numbers and group assignments were sequentially encoded and placed in opaque, consecutively numbered envelopes. After obtaining consent, researchers opened the sealed envelopes in order and assigned participants to either the experimental group (propolis) or the control group (placebo), with 30 participants in each group.Read full original descriptionShow less
Study on the Function of Taiwan Green Propolis in Reducing Blood Lipids and Body Fat in Sub-healthy Groups: MASLD
This study investigates the effectiveness of Taiwanese green propolis in reducing blood lipids and body fat in sub-healthy individuals. The study design follows a parallel, double-blind, randomized assignment approach, dividing participants into an experimental group (propolis) and a control group (placebo). Researchers explained the study plan to participants, and after obtaining signed informed consent, participants were randomly assigned using a web-based program that generated random serial numbers. The randomization was stratified by gender (male-to-female ratio of 1:1) and physiological age groups (maturity, middle age, menopause, post-menopause, and old age). Serial numbers and group assignments were sequentially encoded and placed in opaque, consecutively numbered envelopes. After obtaining consent, researchers opened the sealed envelopes in order and assigned participants to either the experimental group (propolis) or the control group (placebo), with 30 participants in each group.
The experimental group received Taiwanese green propolis (which can be stored at room temperature) in capsule form, containing 500 mg/ml of propolis extract per capsule. Participants took two capsules before breakfast and two before dinner, totaling four capsules per day for 12 weeks. The control group received a placebo with the same dosage and administration method. All participants were instructed not to deliberately change their daily diet or exercise routines during the study. To assess adherence, participants recorded their daily propolis capsule intake. Additionally, the Health Belief Model questionnaire and the EQ-5D-5L quality of life questionnaire were used to evaluate whether the intervention with propolis, along with dietary and exercise education, contributed to increased awareness of health behaviors and improvements in quality of life.
The primary outcomes of the study include changes in blood lipids, body fat, blood glucose levels, liver fat, and liver fibrosis. The secondary outcomes focus on the correlation between health behavior awareness and quality of life.
Keywords: Taiwanese green propolis, sub-health, blood lipids, body fat, Health Belief Model, quality of life.
Inclusion: Aged 18 to 80 years; Meet any of the following dyslipidemia indicators:; Total cholesterol (TC) > 200 mg/dL; Triglycerides (TG) > 200 mg/dL; LDL cholesterol > 130 mg/dL; Overweight or obese (BMI ≥ 27) with abnormal waist circumference:; Male > 90 cm; Female > 80 cm; Not currently receiving any lipid-lowering medication treatment. MASLD.
Exclusion: Allergic to honey, propolis, various pollens, or alcohol; Individuals with psychiatric disorders or cognitive impairments; Pregnant or breastfeeding women; Individuals with significant endocrine disorders or major diseases of the heart, liver, kidneys, or other organs; Individuals with swallowing difficulties; Individuals with dementia, impaired consciousness, or other cognitive disorders preventing informed consent; Individuals already receiving formal lipid-lowering drug therapy; Individuals with comorbid diabetes, chronic kidney disease, or isolated LDL > 190 mg/dL.