Developing a Prediction Tool Using Brain Monitoring for Critically Ill Brain Patients
Studies whether brain monitoring data can predict recovery in adults with serious brain injuries.
Plain-language title generated from the registry record
Registry title: Development and Validation of a Prognostic Model for Neurocritical Patients Using Multimodal Brain Monitoring
Key facts
- Where
- Changsha, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07115459, who can take part
Where in China
- XiangyaHospital of Central South UniversityChangsha, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Xiangya Hospital of Central South University
- Trial code
- NCT07115459
- Record updated
- 17 September 2026
- Original description
This study aims to develop and validate a prognostic model for neurocritical patients using multimodal brain monitoring data. By combining data from various monitoring techniques such as EEG, TCD, and NIRS, this model will help predict 90-day outcomes (awake, comatose, or deceased) and support personalized treatment decisions. The study is observational and involves no experimental interventions.Read full original descriptionShow less
Protocol for Developing and Validating a Multimodal Brain Monitoring-Based Prognostic Model for Neurocritical Patients: A Prospective, Observational, Multicenter Cohort Study
This study aims to develop and validate a prognostic model for neurocritical patients using multimodal brain monitoring data. By combining data from various monitoring techniques such as EEG, TCD, and NIRS, this model will help predict 90-day outcomes (awake, comatose, or deceased) and support personalized treatment decisions. The study is observational and involves no experimental interventions.
Inclusion: Aged 18-80 years, no gender restrictions; Diagnosed with acute brain injury (ABI), including one of the following: large cerebral infarction, supratentorial large-volume intracerebral hemorrhage, subarachnoid hemorrhage, or severe traumatic brain injury, with imaging evidence (CT or MRI) supporting the diagnosis; On ICU admission, Glasgow Coma Scale (GCS) eye response = 1 (no eye opening) and motor score ≤ 5 (does not follow commands); or within 48 hours, neurological deterioration with no eye opening and motor score reduced to ≤ 5 (total GCS score ≤ 8); Able to undergo continuous multimodal monitoring, with an expected ICU stay of ≥72 hours; Informed consent signed by the family or legal representative.
Exclusion: Pre-existing severe neurological disorders such as epilepsy, severe encephalopathy, or chronic intracranial conditions (e.g., brain tumors or hydrocephalus); Inability to perform multimodal monitoring due to technical issues (e.g., equipment failure or sensor installation problems); Confirmed brain death on admission or imaging showing irreversible brain herniation; Severe trauma unrelated to brain injury (e.g., multiple fractures, spinal cord injuries, or visceral rupture) that may interfere with brain function monitoring or outcome assessment; Predicted survival time <24 hours after admission, or family members choose to withdraw treatment; Refusal to participate in the study by the patient or their legal representative.