Surgery to reopen blocked large brain arteries in acute stroke
Tests combined surgery to reopen blocked large brain arteries in adults with acute stroke.
Key facts
- Who runs it
- Tianjin Huanhu Hospital
- Where
- Tianjin, ChinaSee the site
- Trial code
- Registry title
- Combined Recanalization Therapy for Acute Large Vessel Occlusion Stroke
- Status
- Recruiting
- People taking part
- 64 people, planned
- Started
- 1 Dec 2024
- Expected to end
- 30 Nov 2026
- Type of study
- Interventional, 2 groupsOne group gets no study treatment, for comparison.
- Treatments tested
- Surgery
- Record updated
- 11 August 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18-75 with a sudden stroke from a blocked large brain artery, where a clot-removal procedure did not reopen the vessel.
- Age
- 18 to 75 years
- Sex
- All sexes can join.
- Disease stage
- Stroke from a blocked middle cerebral artery (MCA), with or without a blocked internal carotid artery (ICA). A clot-removal procedure (thrombectomy) failed, with a TICI score of 0-1. ASPECTS of 6 or higher. Time from onset to surgery expected to be 24 hours or less. For stroke noticed after waking, there must be a mismatch between the damaged brain area and the area still at risk.
- Earlier treatment
- Must have had a clot-removal procedure that did not work. Must not have had earlier brain or neck artery bypass surgery.
Main reasons for not taking part
- Bleeding vessel disease such as an aneurysm or vascular malformation
- Heart attack, unstable angina or heart failure in the last 6 months
- Pregnancy or the period around birth
- Blood clotting disorder, or platelets below 100×10^9/L
- Uncontrolled diabetes or uncontrolled high blood pressure
The registry criteria, word for word
Show all 22 criteriaShow less
Who can take part
- Age: 18-75
- According to the current guidelines, there is a MT indication
- Before stroke, mRS ≤2
- ASPECTS ≥6
- MCA occlusion, with or without ICA occlusion
- MT unsuccessful, TICI score 0-1
- Time from onset to craniotomy expected to be 24 hours or less
- Post-awakening stroke with mismatch between the infarct zone and the penumbra zone
Who cannot take part
- unstable angina or myocardial infarction, congestive heart failure within the previous 6 months
- previous treatment with intracranial or extracranial vascular bypass surgery
- Received a clinical trial drug or device within 30 days prior to screening, or is participating in another clinical trial
- Comorbid hemorrhagic vascular disease such as intracranial aneurysm or vascular malformation or other planned cerebrovascular surgery that may alter cerebral hemodynamics or lead to stroke
- Hematologic disorders resulting in coagulation disorders
- Combination of other diseases with a life expectancy of less than 2 years; and
- Uncontrolled hypertension with sitting systolic blood pressure >180 mmHg or sitting diastolic blood pressure >110 mmHg
- other diseases or medical history that, in the investigator's judgment, may affect the efficacy or safety evaluation of this study
- allergy to iodine or X-ray contrast media, creatinine >3.0 mg/dl or other contraindications to arteriography
- Uncontrolled diabetes mellitus, fasting blood sugar (FBS) >16.7 mmol/L
- Severe hepatic dysfunction, defined as serum alanine aminotransferase (ALT) and/or alanine aminotransferase (AST) >3 times the upper limit of normal
- Platelets <100×109 /L
- Pregnancy or perinatal period
- contraindication to general anesthesia or craniotomy
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Where in China
- Tianjin Huahu HospitalTianjin, ChinaContact: Gao KaimingTaking people
About the trial
What the trial wants to find out
The purpose of this clinical trial is to evaluate the efficacy and safety of combined recanalization therapy in patients who cannot be recanalized by acute large vessel occlusive stroke. The main questions it aims to answer are:
Read full original descriptionShow less
1、Proportion of subjects with mRs score of 0-1 at 90 days after surgery
Participants will:
1、In acute large vessel occlusive stroke, if traditional means cannot be recanalized, combined recanalization surgery (including arteriotomy and thrombectomy, cerebrovascular bypass surgery) is performed.
The 2 groups in the trial
- experiment group（surgical treatment）Treatment being tested
Treatment: Surgery
- control group（conservative therapy）No study treatment, for comparison
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Combined Recanalization Therapy for Acute Large Vessel Occlusion Stroke
- Plain-language title
- Surgery to reopen blocked large brain arteries in acute strokeGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT07115511, who can take part
- Record updated
- 11 August 2025