Checking vascular risk factors in people with late-onset seizures
Screens people with new seizures after middle age for vascular risk factors like blood pressure.
Plain-language title generated from the registry record
Registry title: Late-Onset Seizures: Trial of Vascular Risk Investigation and Treatment
Key facts
- Where
- Borås, Gothenburg, and Malmö, SwedenSee the 3 sites
Where in Sweden
- Södra Älvsborg SjukhusBorås, SwedenTaking people
- Salgrenska University hospitalGothenburg, SwedenTaking people
- Skånes universitetssjukhusMalmö, SwedenTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Sahlgrenska University Hospital
- Trial code
- NCT07116330
- Record updated
- 3 March 2026
- Original description
A growing body of evidence suggests patients with late-onset seizures are at an increased risk of stroke, but the potential for reducing cardiovascular morbidity through risk factor screening and management is unknown.Read full original descriptionShow less
Late-Onset Seizures: Trial of Vascular Risk Investigation and Treatment
A growing body of evidence suggests patients with late-onset seizures are at an increased risk of stroke, but the potential for reducing cardiovascular morbidity through risk factor screening and management is unknown.
The investigators aim to determine whether individuals with new-onset unprovoked seizures after middle age should undergo vascular risk assessment. In a cluster project the investigators assess the effect of vascular risk factor screening in an observational study as well as a cohort study.
The project has two interlinked components: a prospective single group study, in which risk factor assessment is performed and subsequent management is followed for one year; and a register-based cohort study examining the long-term effects of the intervention on a system level.
Inclusion: Clinical study:; First assessment for unprovoked seizures or epilepsy with onset after age 50 -- - vascular risk factor evaluation per the new routine at participating care givers; Register study:; age ≥50 with a first-ever outpatient appointment to one of the participating clinics and; a first-listed diagnostic code for seizures or epilepsy (ICD-10: R568, G40).
Exclusion: preexisting seizures/epilepsy, as demonstrated by a registered diagnostic code for seizures (ICD-10: R568, G40, G41) or a dispensed antiseizure medication (ATC-code: N03) more than 3 months before the initial consultation; Progressive brain disease (tumour or degenerative); Register study:; a registered diagnostic code for stroke or TIA (ICD-10: I61, I63, I64, or G45 except G454) before the initial consultation, or; progressive brain disease, as indicated by diagnostic codes or drug prescriptions suggestive of brain tumors (ICD-10: C71, D33, D43, C793) or; neurocognitive disorders (ICD-10: F00-F03, F051, G30, G318, G912; ATC code: N06D); Clinical study:; Inability to consent.