Pain Relief Trial of Ropivacaine Given in the Chest After Heart Surgery
Tests ropivacaine, a numbing medicine, against saltwater in adults after heart surgery.
Plain-language title generated from the registry record
Registry title: Intrapleural Ropivacaine Infusion in Cardiac Surgery
Key facts
- Where
- Saint Petersburg and Vladivostok, RussiaSee the 2 sites
- Phase
- Phase 4
Where in Russia
- Saint-Petersburg university hospitalSaint Petersburg, RussiaTaking people
- Primorskiy general hospital #1Vladivostok, RussiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Saint Petersburg State University, Russia
- Trial code
- NCT07116343
- Record updated
- 10 March 2026
- Original description
For many patients, a primary source of postoperative pain following cardiac surgery is the presence of pleural drains, which the surgeon places at the end of the operation and maintains for 1 to 3 days. One promising method of pain management after cardiac surgery is interpleural analgesia, particularly when traditional analgesic methods, such as systemic opioids or epidural anesthesia, may be limited due to the risk of complications. Interpleural analgesia involves the introduction of local anesthetics directly into the pleural cavity through drainage tubes placed after cardiac surgery. This method targets pain receptors in the chest area, providing effective analgesia without significant systemic effects. Several clinical studies have confirmed the safety and efficacy of intrapleural administration of anesthetics after thoracic surgery. The aim of this randomised double-blind placebo controlled study is to test the hypothesis that, in patients after cardiac surgery, the quality of recovery from anesthesia with intrapleural use of ropivacaine is superior to that with a placebo.Read full original descriptionShow less
Intrapleural Ropivacaine Infusion in Cardiac Surgery: Randomized Double-blind Controlled Study
For many patients, a primary source of postoperative pain following cardiac surgery is the presence of pleural drains, which the surgeon places at the end of the operation and maintains for 1 to 3 days. One promising method of pain management after cardiac surgery is interpleural analgesia, particularly when traditional analgesic methods, such as systemic opioids or epidural anesthesia, may be limited due to the risk of complications. Interpleural analgesia involves the introduction of local anesthetics directly into the pleural cavity through drainage tubes placed after cardiac surgery. This method targets pain receptors in the chest area, providing effective analgesia without significant systemic effects. Several clinical studies have confirmed the safety and efficacy of intrapleural administration of anesthetics after thoracic surgery. The aim of this randomised double-blind placebo controlled study is to test the hypothesis that, in patients after cardiac surgery, the quality of recovery from anesthesia with intrapleural use of ropivacaine is superior to that with a placebo.
Inclusion: Scheduled cardiac surgery using a standard median sternotomy; Planned opening of the pleural cavities; Age more than 18 years; Signed informed consent to participate in the study.
Exclusion: Redo surgery; Contraindications for ropivacaine.