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Ultrasonographic Assessment of Muscle Morphology, Function, and Clinical Findings in Spastic Cerebral Palsy

Key facts

Who runs it
Kocaeli University
Where
Türkiye1 site in 1 countryChoose a country to see its sites
Trial code
Status
Recruiting
People taking part
36 people, planned
Started
15 Dec 2025
Planned end
30 Jun 2026
Type of study
Observational
Record updated
3 February 2026

Who can take part

Age
4 years to 18 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 12 criteriaShow less

Who can take part

  • Diagnosis of spastic cerebral palsy (SCP) according to the criteria defined by Rosenbaum et al. (2007)
  • Age between 4 and 18 years
  • Gross Motor Function Classification System (GMFCS) Level I, II, or III
  • Manual Ability Classification System (MACS) Level I, II, III, or IV

Who cannot take part

  • Current treatment with oral or intrathecal antispastic medications
  • Diagnosis of neuromuscular disorders other than cerebral palsy (e.g., hereditary neuropathy, myopathy)
  • History of orthopedic surgery or selective dorsal rhizotomy involving the target muscles
  • Acute infection, febrile illness, or severe systemic disease (e.g., advanced heart failure, respiratory insufficiency) that may compromise the safety of assessments
  • Non-spastic types of cerebral palsy (e.g., dyskinetic, ataxic)
  • Presence of muscle contractures or fixed deformities in the limbs selected for ultrasound and clinical assessment
  • Cognitive or behavioral impairments that prevent cooperation during ultrasound or clinical evaluation
  • Botulinum toxin-A (BoNT-A) injection applied to the target muscles within the last 6 months

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 4 and 18 years old?

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

This study focuses on children with spastic cerebral palsy and aims to examine how muscle morphology and tissue characteristics, as assessed by ultrasound, may relate to functional motor abilities. It is designed as a prospective, cross-sectional, observational study. Planned ultrasound-based assessments include parameters such as muscle thickness, pennation angle, fascicle length, echo intensity, tissue stiffness (via shear wave elastography), and microvascular flow (via superb microvascular imaging). These measurements are intended to be compared with standard clinical evaluations, including the GMFCS, GMFM-66, MAS, MACS, and Tardieu Scale. The study seeks to contribute to a better understanding of the relationship between muscle architecture and functional outcomes, with the goal of generating insights that may inform individualized rehabilitation planning.

The group in the trial

  • Spastic CP Cohort

    Ambulatory children with spastic cerebral palsy classified within GMFCS levels I to III. Participants undergo clinical and ultrasound-based assessments to evaluate muscle morphology, functional properties, and their relationship with motor function.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Evaluation of the Relationship Between Ultrasonographic Muscle Morphology, Functional Properties, and Clinical Parameters in Children With Spastic Cerebral Palsy
Fit questions
Built from NCT07118228, who can take part
Record updated
3 February 2026