Tests silymarin, a plant supplement, added to treatment for stable COPD
Tests silymarin, a plant supplement, compared with a placebo in adults with stable COPD.
Plain-language title generated from the registry record
Registry title: Effect of Silymarin as Add on Therapy on Oxidative Stress, Pulmonary Function and Quality of Life in Stable COPD Patients.
Key facts
- Where
- Dhaka, BangladeshSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 80 years old?
Source: NCT07123922, who can take part
Where in Bangladesh
- BSMMUDhaka, BangladeshNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
- Trial code
- NCT07123922
- Record updated
- 14 August 2025
- Original description
The goal of this clinical trial is to learn if Silymarin works to reduce oxidative stress, improve pulmoary function and quality of life in stable COPD patients. It will also learn about the safety of drug Silymarin. The main questions it aims to answer are:Read full original descriptionShow less
Effect of Silymarin as Add on Therapy on Oxidative Stress, Pulmonary Function and Quality of Life in Stable COPD Patients; A Randomized Double-Blind Placebo-Controlled Trial
The goal of this clinical trial is to learn if Silymarin works to reduce oxidative stress, improve pulmoary function and quality of life in stable COPD patients. It will also learn about the safety of drug Silymarin. The main questions it aims to answer are:
Does drug Silymarin reduce oxidative stress, improve pulmonary function and quality of life in stable COPD patients? What medical problems do participants have when taking drug Silymarin? Researchers will compare Silymarin to a placebo (a look-alike substance that contains no drug) to see if Silymarin works to treat COPD.
Participants will:
Take Silymarin or a placebo thrice daily every day for 3 months. Baseline and 3 months after plasma Malondealdehyde, erythrocyte Glutathione , FEV1, SGRQ-C score will be monitored.
Inclusion: Diagnosed case of COPD according to GOLD guideline (post bronchodilator FEV1/FVC < 0.7); Age 40-80 years; No exacerbation or hospitalization due to exacerbation in the last 1 month.
Exclusion: • COPD exacerbation; Presence of other respiratory diseases like asthma, bronchiectasis, interstitial lung disease, tuberculosis or lung cancer; Diagnosed case of diabetes mellitus, liver disease, heart disease, kidney stones and disease, hyperparathyroidism, other malignancies; Use of other antioxidant drugs like Vitamin C, E, N acetylcysteine within last 1 months; Known hypersensitivity to Silymarin.