Esophagus stretchiness and surface changes during ablation for dysplastic Barrett's esophagus
Measures esophagus changes in people having radiofrequency ablation for dysplastic Barrett's esophagus.
Key facts
- Who runs it
- Mayo Clinic
- Where
- Rochester, United StatesSee the site
- Trial code
- Registry title
- Impact of RFA on Esophageal Distensibility and Mucosal Impedance
- Status
- Recruiting
- People taking part
- 10 people, planned
- Started
- 19 Aug 2025
- Expected to end
- 31 Jul 2027
- Type of study
- Observational
- Treatments tested
- Radiofrequency ablation alone
- Record updated
- 14 October 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with Barrett's esophagus with abnormal cells (dysplasia) or early cancer in the lining (intramucosal carcinoma), who will get radiofrequency ablation. Extra measurements of the esophagus are taken during their usual upper endoscopies.
- Age
- 18 years or older
- Sex
- Male or female
- Disease stage
- Barrett's esophagus with dysplasia or intramucosal carcinoma (IMCa), confirmed by tissue testing.
- Earlier treatment
- People must not have had esophageal ablation before. People must be able to take high-dose proton pump inhibitor (PPI) therapy (such as omeprazole 40 mg BID). They must be willing to have several rounds of endoscopic eradication therapy (EET).
Main reasons for not taking part
- Past narrowing (stricture) of the esophagus, achalasia, or esophageal or stomach surgery
- Esophageal cancer treated with radiation or chemotherapy in the past
- Pregnancy
- Slow stomach emptying confirmed by a 4-hour gastric emptying study, or a glucagon like peptide 1 agonist injection within a few days before the endoscopy
- Adults who cannot give consent for themselves
The registry criteria, word for word
Show all 13 criteriaShow less
Who can take part
- Male or female ≥ 18 years of age
- Confirmed histologic diagnosis of BE with dysplasia or intramucosal carcinoma (IMCa)
- Ability to take high-dose proton pump inhibitor (PPI) therapy (such as omeprazole 40 mg BID)
- Willing to undergo multiple rounds of endoscopic eradication therapy (EET) for management of BE (which is the guideline clinical recommendation for management of this disease)
Who cannot take part
- History of esophageal cancer treated with radiation or chemotherapy
- Received injection of glucagon like peptide 1 agonists within a few days prior to EGD
- History of esophageal ablation
- History of esophageal stricture
- History of esophageal or gastric surgery
- History of achalasia
- History of delayed gastric emptying confirmed by 4-hour gastric emptying study
- Pregnancy
- Adults lacking the capacity to consent for self
Where in United States
- Mayo ClinicRochester, United StatesContact: Mariah J. RobranTaking people
About the trial
What the trial wants to find out
Patients undergoing ablative therapy for management of dysplastic Barrett's Esophagus (BE) will have decreased distensibility over the course of treatment, but improvement in mucosal impedance as BE epithelia is replaced by neosquamous epithelia. This information may lead to further research in predicting therapeutic response and complications. The purpose of this research is to collect information while measuring changes related to the esophagus in patients that receive radiofrequency ablation (RFA) for dysplastic Barrett's Esophagus (BE) or esophageal cancer. Study participation includes measurements of the esophagus with the use of two different devices. This takes place during clinically indicated upper endoscopies during the timeframe the participant is receiving RFA treatments. This process will take up to an additional 10 minutes during the upper endoscopy and be done while the participant is sedated.
Treatments tested
- Radiofrequency ablation alone
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Assessment of Esophageal Distensibility and Mucosal Impedance in Dysplastic Barrett's Esophagus Patients Undergoing Radiofrequency Ablation
- Plain-language title
- Esophagus stretchiness and surface changes during ablation for dysplastic Barrett's esophagusGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Record updated
- 14 October 2026