Using a 3D model to guide surgery for prostate cancer spread to lymph nodes
Tests a 3D model made from PSMA scans to guide surgery in prostate cancer.
Plain-language title generated from the registry record
Registry title: Navigation, Outcomes and Quality-of-life in Prostate Cancer Patients Undergoing PSMA-targeted Surgery
Key facts
- Where
- Hamburg, GermanySee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 78 years old?
Source: NCT07129551, who can take part
Where in Germany
- Anke RenterHamburg, GermanyNot yet recruiting
- Martini KlinikHamburg, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Martini-Klinik am UKE GmbH
- Trial code
- NCT07129551
- Record updated
- 12 January 2026
- Original description
As part of a feasibility study, it's planned to use a 3D virtual mixed reality model with prostate cancer patients who show signs of lymph node metastasis and are scheduled for surgery. The model is based on PSMA PET imaging performed prior to surgery and will be evaluated by surgeons, the surgical team, and patients as part of the consultation process. First, the researcher investigates whether the removal of lymph node metastases has improved compared to the data in the literature . In addition, the study examines how the 3D model influences the movement of surgical instruments and the efficiency of surgical removal of lymph node metastases. To this end, the analyzed recorded video and position data of the instruments used during procedures performed with a surgical robot. It's also an aim to develop two methods-using landmarks and visual position tracking-for more targeted navigation during surgery. Additionally, short-term results examine, such as PSA response rates, as an indication of successful lymph node metastasis removal and patient quality of life.Read full original descriptionShow less
Navigation, Outcomes and Quality-of-life in Prostate Cancer Patients Undergoing PSMA-targeted Surgery
As part of a feasibility study, it's planned to use a 3D virtual mixed reality model with prostate cancer patients who show signs of lymph node metastasis and are scheduled for surgery. The model is based on PSMA PET imaging performed prior to surgery and will be evaluated by surgeons, the surgical team, and patients as part of the consultation process. First, the researcher investigates whether the removal of lymph node metastases has improved compared to the data in the literature . In addition, the study examines how the 3D model influences the movement of surgical instruments and the efficiency of surgical removal of lymph node metastases. To this end, the analyzed recorded video and position data of the instruments used during procedures performed with a surgical robot. It's also an aim to develop two methods-using landmarks and visual position tracking-for more targeted navigation during surgery. Additionally, short-term results examine, such as PSA response rates, as an indication of successful lymph node metastasis removal and patient quality of life.
Inclusion: Cohort A:; Patients with hormone-sensitive prostate cancer scheduled for radical prostatectomy with pelvic lymph node dissection; <3 PSMA-PET-avid lymph node metastases (PSMA expression score >2) in the pelvis; Cohort B:; Patients with hormone-sensitive recurrent prostate cancer after radical prostatectomy with planned pelvic salvage lymph node dissection; <3 PSMA-PET-avid lymph node metastases (PSMA expression score >2) in the pelvis; PSA value <2ng/ml.
Exclusion: contraindication for surgical intervention; androgen deprivation therapy (ADT) within the last 3 months; Estimated life expectancy <10 years.