Tests tulisokibart for radiographic axial spondyloarthritis, a type of arthritis
Tests tulisokibart against placebo in adults with spine and pelvis arthritis.
Plain-language title generated from the registry record
Registry title: A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)
Key facts
- Where
- Arlington, Aventura, Baltimore, Brandon, Chandler, Chicago, Chula Vista, Cooper City, Corpus Christi, Denver, Duncansville, Flagstaff, Fort Worth, Fullerton, Gilbert, Glendale, Houston, Huntington Beach, Irving, Kalispell, Kansas City, Lincoln, Murfreesboro, Palmetto Bay, Philadelphia, Portland, Red Oak, Rockville, Santa Fe, St Louis, The Woodlands, Thousand Oaks, Tomball, Tucson, Upland, and Willowbrook, United StatesSee the 37 sites
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07133633, who can take part
Where in United States
- Rheumatology Associates (Site 0055)Arlington, United StatesTaking people
- Arthritis and Rheumatic Disease Specialties (Site 0016)Aventura, United StatesTaking people
- John Hopkins University (Site 0052)Baltimore, United StatesTaking people
- Bay Area Arthritis and Osteoporosis (Site 0041)Brandon, United StatesTaking people
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Chandler (Site 0036)Chandler, United StatesTaking people
- Chicago Arthritis & Regenerative Medicine (Site 0042)Chicago, United StatesTaking people
- TriWest Research Associates - Chula Vista (Site 0013)Chula Vista, United StatesNo longer taking part
- GNP Research - Hollywood (Site 0020)Cooper City, United StatesTaking people
- Arthritis Care of Texas (Site 0048)Corpus Christi, United StatesTaking people
- Denver Arthritis Clinic (Site 0064)Denver, United StatesTaking people
- Altoona Center for Clinical Research (Site 0004)Duncansville, United StatesTaking people
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Flagstaff (Site 0021)Flagstaff, United StatesTaking people
- Lone Star Arthritis & Rheumatology Associates, P.C. (Site 0028)Fort Worth, United StatesTaking people
- Providence Medical Foundation (Site 0049)Fullerton, United StatesTaking people
- Arizona Arthritis & Rheumatology Associates, P.C. - Gilbert (Site 0022)Gilbert, United StatesTaking people
- AARA Arizona Arthritis & Rheumatology Associates, P.C. - Glendale (Site 0056)Glendale, United StatesTaking people
- Provecta Research Network LLC (Site 0054)Houston, United StatesTaking people
- The University of Texas Health Science Center at Houston (Site 0065)Houston, United StatesTaking people
- Newport Huntington Medical Group (Site 0005)Huntington Beach, United StatesTaking people
- AARA Clinical Research - Lone Star Arthritis and Rheumatology Associates - Irving (Site 0032)Irving, United StatesTaking people
- Logan Health Rheumatology (Site 0015)Kalispell, United StatesTaking people
- Kansas City Physician Partners (Site 0027)Kansas City, United StatesTaking people
- Physician Research Collaboration, LLC (Site 0057)Lincoln, United StatesTaking people
- AARA Clinical Research - Murfreesboro Medical Clinic (Site 0029)Murfreesboro, United StatesTaking people
- Innovation Medical Research Center (Site 0012)Palmetto Bay, United StatesTaking people
- Perelman Center for Advanced Medicine (Site 0060)Philadelphia, United StatesTaking people
- Oregon Health & Science University (Site 0059)Portland, United StatesTaking people
- Epic Medical Research (Site 0061)Red Oak, United StatesTaking people
- Arthritis and Rheumatism Associates - Rockville (Site 0019)Rockville, United StatesTaking people
- Inspire Santa Fe Medical Group (Site 0011)Santa Fe, United StatesTaking people
- Velocity Clinical Research - West County Rheumatology, St. Louis (Site 0038)St Louis, United StatesTaking people
- Advanced Rheumatology of Houston (Site 0001)The Woodlands, United StatesTaking people
- Cohen Medical Centers (Site 0034)Thousand Oaks, United StatesTaking people
- DM Clinical Research - TRA (Site 0010)Tomball, United StatesTaking people
- Arizona Arthritis & Rheumatology Associates, P.C. - Tucson (Site 0025)Tucson, United StatesTaking people
- Inland Rheumatology Clinical Trials, Inc. (Site 0002)Upland, United StatesTaking people
- Willow Rheumatology and Wellness, PLLC (Site 0035)Willowbrook, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Merck Sharp & Dohme LLC
- Trial code
- NCT07133633EU 2025-521059-21-00
- Record updated
- 23 October 2026
- Original description
Researchers are looking for new ways to treat radiographic axial spondyloarthritis (r-axSpA). R-axSpA is a type of arthritis that causes pain, stiffness, and inflammation (swelling) in the spine and joints in the pelvis (hip bone). Radiographic means the damage it causes can be seen on X-rays.Read full original descriptionShow less
A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Tulisokibart in Participants With Radiographic Axial Spondyloarthritis (Ankylosing Spondylitis)
Researchers are looking for new ways to treat radiographic axial spondyloarthritis (r-axSpA). R-axSpA is a type of arthritis that causes pain, stiffness, and inflammation (swelling) in the spine and joints in the pelvis (hip bone). Radiographic means the damage it causes can be seen on X-rays.
This study will help find out if a study medicine called tulisokibart can treat symptoms of r-axSpA. Researchers will look at different doses of tulisokibart.
Researchers want to know if at least one of the study doses of tulisokibart works better than a placebo to improve r-axSpA symptoms. A placebo looks like the study medicine but has no study medicine in it. Using a placebo helps researchers better understand the effects of the study medicine.
Inclusion: The main inclusion criteria include but are not limited to the following:; Has a clinical diagnosis of axial spondyloarthritis (axSpA) and meets the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axSpA including ≥3 months of back pain with age at symptom onset <45 years; Meets the radiographic criterion of the modified New York criteria for ankylosing spondylitis (AS) as determined by central reading at Screening; Has active disease at Screening and Randomization; Has a history of inadequate response (IR)/intolerance to nonsteroidal anti-inflammatory drugs (NSAIDs) and is biologic disease-modifying antirheumatic drug (bDMARD)-naive, or has a history of IR/intolerance to up to a maximum of 2 bDMARD classes.
Exclusion: Has a history of cancer (except fully treated non-melanoma skin cancers or cervical carcinoma in situ after complete surgical removal) within the last 5 years; Has any active infection; Has known allergies, hypersensitivity, or intolerance to tulisokibart or its excipients; Has any arthritis with onset before age 17 years or current diagnosis of inflammatory joint disease other than radiographic axial spondyloarthritis (r-axSpA) (such as, but not limited to, rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis (PsA), systemic sclerosis, myositis, etc.), or any other conditions that may, in the judgment of the investigator, interfere with the assessment of r-axSpA; The main exclusion criteria include but are not limited to the following:.