NCT07137013Completed
Periodontitis Severity in Patients With Diabetic Retinopathy
Evaluation of the Relationship Between Periodontal Disease Severity and Retinal Layer Thickness in Patients With Diabetic Retinopathy Using Optical Coherence Tomography
Source: ClinicalTrials.gov · Last updated 22 Aug 2025
Brief summary (registry, in English)
The aim of this observational study is to investigate the relationship between periodontal disease severity and retinal layer thickness in patients diagnosed with diabetic retinopathy (DR), using optical coherence tomography (OCT) for assessment. The main question this study seeks to answer is: Do measurable changes in retinal layer thickness occur as periodontal disease severity increases in patients with diabetic retinopathy? Participants will include adult individuals with a confirmed clinical diagnosis of DR. Periodontal status will be assessed through standard clinical parameters, including plaque index, probing pocket depth, clinical attachment loss, and bleeding on probing. Retinal layer thickness will be measured using high-resolution OCT and OCT angiography (OCTA) devices. The study aims to analyze potential associations between periodontal disease severity and morphological as well as vascular changes in the retina.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 100 (actual)
- First submitted
- 11 Aug 2025
- Start date
- 24 Feb 2025
- Primary completion date
- 12 May 2025
- Lead sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
- Diseases
- Diabetic eye disease
- NCT number
- NCT07137013
What you commit to
- Study type: Observational
- Participants enrolled: 100
- From 24 Feb 2025 to the primary completion date, 12 May 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients taking immunosuppressive medications, oral contraceptives, or bisphosphonates
- Patients undergoing refractive or intraocular surgery
- Chronic use of medications affecting periodontal tissues (cyclosporine A, phenytoin)
Other illness
- Patients with any autoimmune disease, osteoporosis, or cancer
- Patients with acute or chronic eye diseases such as vitreoretinal, optic nerve, or choroidal vascular diseases, cataracts, glaucoma, retinal degeneration, uveitis, Behçet's disease, or scleritis
- Presence of active infectious disease (acute hepatitis, tuberculosis, AIDS)
Other
- Pregnancy
- Patients taking antioxidant supplements
Who the study is looking for
- Men and women aged 60 and over
- Those without systemic disease (control group)
- Patients diagnosed with diabetic retinopathy
- Patients diagnosed with diabetes mellitus (HbA1c\>6)
Age in the registry: 60 years to 85 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Ophthalmology of the Faculty of Medicine of Recep Tayyip Erdogan University Coordinator of this site? Confirm its status | Rize | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.