Zinc supplements to help botulinum toxin work longer in cervical dystonia
Tests zinc citrate against placebo in adults with cervical dystonia receiving Botox.
Key facts
- Who runs it
- University of Florida
- Where
- Gainesville, United StatesSee the site
- Trial code
- Registry title
- Zinc as an Adjunctive Therapy for Cervical Dystonia
- Status
- Recruiting
- Phase
- Phase 2
- People taking part
- 25 people, planned
- Started
- 1 Jun 2026
- Expected to end
- 31 May 2027
- Type of study
- Interventional, 2 groups
- Treatments tested
- Zinc citrate
- Placebo
- Record updated
- 15 May 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with cervical dystonia (neck muscle spasms) who get regular Botox injections. It tests whether daily zinc makes the Botox effect last longer.
- Age
- 18 to 89 years
- Sex
- All sexes
- Disease stage
- Diagnosed cervical dystonia.
- Earlier treatment
- Must have been receiving regular BoNT type A (Botox) injections for at least six months.
Main reasons for not taking part
- Known allergy or intolerance to zinc.
- Serious other illnesses or medicines that could affect the study results.
- Pregnant or breastfeeding women.
- Already taking a zinc supplement that, with the study zinc, would go above 40 mg elemental zinc per day.
The registry criteria, word for word
Show all 7 criteriaShow less
Who can take part
- Adults aged 18-89 years
- Diagnosed with cervical dystonia
- Receiving regular BoNT type A (Botox) injections for at least six months
Who cannot take part
- Significant comorbidities or concurrent medications that could interfere with study outcomes
- Known allergy or intolerance to zinc
- Pregnant or breastfeeding women
- Already taking a zinc supplement which would exceed tolerable upper intake level in adults (40 mg elemental zinc per day) with addition of zinc study supplement
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 89 years old?
Where in United States
- Norman Fixel Institute for Neurological DiseasesGainesville, United StatesContact: Lauren Fanty, MD (principal investigator)Taking people
About the trial
What the trial wants to find out
The goal of this clinical trial is to evaluate if supplemental zinc can prolong the duration of benefit of botulinum toxin injections in cervical dystonia patients receiving care at the University of Florida.
Read full original descriptionShow less
The main aims are:
1. To evaluate the efficacy of zinc citrate supplementation in prolonging the duration of symptom relief provided by botulinum toxin type A (Botox) injections in cervical dystonia patients. 2. To assess the safety and tolerability of zinc supplementation in this patient population. 3. To analyze the potential influence of zinc supplementation on the quality of life and functional outcomes in cervical dystonia patients receiving Botox.
Researchers will compare zinc citrate to a placebo (a look-alike substance that contains no active drug) to see if zinc works to extend the effects of Botox.
Participants will:
Take zinc citrate or a placebo every day for 3 months, then cross over to the alternative treatment for another 3 months.
Visit the clinic every 3 months for Botox injections, check ups and surveys.
The 2 groups in the trial
- Zinc firstTreatment being tested
Encapsulated zinc citrate 30 mg orally daily for 3 months followed by placebo capsule matching zinc daily for 3 months
Treatment: Zinc citrate and Placebo
- Placebo firstTreatment being tested
Placebo capsule matching zinc daily for 3 months, followed by encapsulated zinc citrate 30 mg orally daily for 3 months
Treatment: Zinc citrate and Placebo
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Evaluation of Supplemental Zinc as an Adjunct to Prolong the Duration of Benefit After Botulinum Toxin Injections in Subjects With Cervical Dystonia
- Plain-language title
- Zinc supplements to help botulinum toxin work longer in cervical dystoniaGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Fit questions
- Built from NCT07140874, who can take part
- Record updated
- 15 May 2026