The Effects of a Probiotic Food Supplement in Hyperuricaemia
Key facts
- Where
- Örebro, SwedenSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07141888, who can take part
Where in Sweden
- Örebro UniversityÖrebro, SwedenContact: Julia KönigTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Örebro University, Sweden
- Trial code
- NCT07141888
- Record updated
- 27 March 2026
- Original description
The overall aim of the project is to determine whether a daily intake of health-promoting bacteria, known as probiotics, with or without a dietary fiber, affects uric acid levels in individuals with elevated levels of uric acid in the blood (hyperuricemia). Additionally, the project will investigate which individuals benefit from this dietary supplement and which do not, based on factors such as gut microbiota composition and function, dietary habits, genetic factors, and inflammatory status. The ultimate goal is to develop a personalized therapy for hyperuricemia.Read full original descriptionShow less
The Effects of a Novel Probiotic Food Supplement in Hyperuricaemia - Towards Development of an Individualised Treatment Strategy
The overall aim of the project is to determine whether a daily intake of health-promoting bacteria, known as probiotics, with or without a dietary fiber, affects uric acid levels in individuals with elevated levels of uric acid in the blood (hyperuricemia). Additionally, the project will investigate which individuals benefit from this dietary supplement and which do not, based on factors such as gut microbiota composition and function, dietary habits, genetic factors, and inflammatory status. The ultimate goal is to develop a personalized therapy for hyperuricemia.
At the beginning of the study, blood samples will be taken to determine uric acid levels and 99 individuals with hyperuricemia will be invited to participate in a 6-week intervention study with daily intake of dietary supplements. To examine the effect of the supplement on various health variables, blood, urine, stool, and breath samples will be collected on several occasions.
To better understand the underlying factors of hyperuricemia, questionnaire data and results from biological will be compared between participants with normal versus elevated uric acid levels. Furthermore, different outcome parameters from questionnaires and samples before and after supplement intake will be compared. In addition, various methods for estimating dietary intake will be investigated and compared with each other.
Inclusion: Signed informed consent prior to any study-related procedures; Age 18-80 years old; BMI range 17.5-40 kg/m2; Blood uric acid above 405 μmol/l (6.8 mg/dl); Willing to abstain from regular consumption of probiotic supplements or food products containing probiotic bacteria (including fermented food and beverages) during the study; Willing to abstain from regular consumption of supplements and medications known to alter gastrointestinal function or inflammatory status during the study.
Exclusion: (Partial) resection of the small intestine or colon; Regular use of urate-lowering treatment (apart from allopurinol) in the month prior to inclusion; Oral or intravenous administration of antibiotics and/or corticosteroids in the 4 months prior to inclusion; Regular use of any non-steroidal anti-inflammatory drug (NSAID) during the last month prior to inclusion (apart from low-dose acetylsalicylic acid); Regular use of probiotic or prebiotic supplementation in the month prior to inclusion; Diagnosis of type 1 diabetes; Diagnosed inflammatory bowel disease (IBD); Current diagnosis of psychiatric disease/s or syndromes; Current diagnosis of neurodegenerative disease; History of complicated gastrointestinal surgery; Any condition or intake of medication which could substantially interfere with the outcome of the study, as decided by the principal investigator's discretion; Recent (within last month) episode of gout; Current pregnancy or breastfeeding; Consumption of more than 9 standard glasses of alcohol-containing drinks per week and/or more than 4 standard glasses per occasion.