Tests nasal stem cell vesicles in stroke patients with cognitive impairment
Tests nasal stem cell-derived vesicles in adults with stroke and memory or thinking problems.
Plain-language title generated from the registry record
Registry title: Induced Pluripotent Stem Cells-derived Small Extracellular Vesicles May Promote Neurological Function and Improve Cognitive Impairment in Acute Ischemic Stroke Patients
Key facts
- Where
- Shanghai, ChinaSee the site
- Phase
- Phase 1/2
Where in China
- Shanghai Sixth People's HospitalShanghai, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hongmei Wang
- Trial code
- NCT07145294
- Record updated
- 28 August 2025
- Original description
This study primarily evaluates whether iEV nasal administration can improve neurological impairment and cognitive dysfunction in patients with acute cerebral infarction and cognitive impairment, and preliminarily explores its clinical efficacy.Read full original descriptionShow less
Induced Pluripotent Stem Cells-derived Small Extracellular Vesicles May Promote Neurological Function and Improve Cognitive Impairment in Acute Ischemic Stroke Patients
This study primarily evaluates whether iEV nasal administration can improve neurological impairment and cognitive dysfunction in patients with acute cerebral infarction and cognitive impairment, and preliminarily explores its clinical efficacy.
Inclusion: Age ≥ 18 years old; Diagnosed with acute ischemic stroke (AIS) according to WHO criteria; Time from onset to enrollment ≤ 2 weeks (stable condition after admission and able to cooperate with cognitive assessment), accompanied by manifestations of cognitive impairment, with a score of < 26 on the Montreal Cognitive Assessment (MoCA) scale; Cerebral MRI or CT scan shows stroke lesions related to the condition; Subjects or their family members voluntarily participate and sign the informed consent form.
Exclusion: A diagnosis of cognitive impairment prior to the onset of AIS; Presence of aphasia, hearing impairment, visual impairment, dysarthria, or other conditions that prevent completion of neuropsychological assessments; Patients with mental illnesses such as depression, anxiety disorder, or schizophrenia; Patients with severe diseases of the heart, liver, lungs, kidneys, or other vital organs; Patients with disturbed consciousness, a history of long-term alcohol consumption, a history of severe head trauma, or those who cannot cooperate with cognitive function tests for various reasons; illiterate patients.