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Gamma tACS in Attention-Deficit/Hyperactivity Disorder

Key facts

Who runs it
Medipol University
Where
Türkiye1 site in 1 countryChoose a country to see its sites
Trial code
Status
Enrolling by invitation
People taking part
60 people, planned
Started
1 Oct 2025
Expected to end
30 Dec 2027
Type of study
Interventional, 5 groupsOne group gets a sham (pretend) treatment, for comparison.
Treatments tested
  • Application tACS- 80 Hz
  • Application tACS -40 Hz
  • Application TACS - (6-80 Hz)
  • Application TACS- Individual Gamma Hz
  • Application TACS- Sham
Record updated
28 August 2025

Who can take part

Age
18 years to 40 years
Sex
Women and men
Healthy volunteers
Can take part

The registry criteria, word for word

Show all 6 criteriaShow less

Who can take part

  • Being between 18 and 40 years of age
  • Receiving an ADHD diagnosis
  • Scoring above 25 on the Montreal Cognitive Assessment (MoCA)
  • Being right-handed

Who cannot take part

  • Use of medications with sedative or stimulant effects
  • Presence of metal brain implants or a pacemaker

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 40 years old?

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder characterized by symptoms of inattention, impulsivity, and hyperactivity. These symptoms are often associated with impairments in executive functions and working memory, which are essential for goal-directed behavior and cognitive control. Deficits in these domains can significantly hinder individuals' academic, social, and daily functioning. Gamma oscillations (30-80 Hz) play a crucial role in cognitive integration, attention, and memory processes, and are thought to emerge from the balance between excitatory and inhibitory neuronal activity.

Read full original descriptionShow less

Transcranial Alternating Current Stimulation (tACS) is a non-invasive brain stimulation technique that modulates neuronal activity through rhythmic electrical currents. Recent studies suggest that gamma-frequency tACS applied to the prefrontal cortex can enhance cognitive performance and attentional processes. In individuals with ADHD, disrupted gamma connectivity and reduced regional gamma power have been associated with attentional deficits. Therefore, gamma tACS may modulate both regional activity and long-range functional connectivity, offering a promising neuromodulation strategy to alleviate ADHD symptoms.

In this context, the present study aims to investigate the effects of bilateral gamma-frequency tACS applied to the prefrontal cortex on attention and executive function performance in individuals with ADHD. Changes in gamma oscillatory activity will be measured using EEG to assess the neurophysiological impacts of stimulation. The study seeks to evaluate whether gamma tACS can serve as a targeted, evidence-based intervention to address the neurofunctional deficits observed in ADHD, potentially offering a novel therapeutic approach.

The 5 groups in the trial

  • 80 Hz GroupTreatment being tested

    Transcranial alternating current stimulation (tACS) at 80 Hz gamma frequency will be applied to the bilateral dorsolateral prefrontal cortex (DLPFC). Each session will last 20 minutes. A total of five sessions will be conducted.

    Treatment: Application tACS- 80 Hz

  • 6-80 Hz GroupTreatment being tested

    Transcranial alternating current stimulation (tACS) at 6-80 Hz theta- gamma frequency will be applied to the bilateral dorsolateral prefrontal cortex (DLPFC). Each session will last 20 minutes. A total of five sessions will be conducted.

    Treatment: Application TACS - (6-80 Hz)

  • Sham GroupSham treatment, for comparison

    Transcranial alternating current stimulation (tACS) sham will be applied to the the bilateral dorsolateral prefrontal cortex (DLPFC). Each session will last 20 minutes. A total of five sessions will be conducted.

    Treatment: Application TACS- Sham

  • 40 Hz GroupTreatment being tested

    Transcranial alternating current stimulation (tACS) at 40 Hz gamma frequency will be applied to the bilateral dorsolateral prefrontal cortex (DLPFC). Each session will last 20 minutes. A total of five sessions will be conducted.

    Treatment: Application tACS -40 Hz

  • Individual Gamma GroupTreatment being tested

    Transcranial alternating current stimulation (tACS) at ındividual gamma frequency will be applied to the bilateral dorsolateral prefrontal cortex (DLPFC). Each session will last 20 minutes. A total of five sessions will be conducted.

    Treatment: Application TACS- Individual Gamma Hz

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Gamma Transcranial Alternating Current Stimulation in Attention Deficit Hyperactivity Disorder
Fit questions
Built from NCT07145593, who can take part
Record updated
28 August 2025